PMID: 8584051Sep 1, 1995Paper

Effect of moderate cooling on contractile responses in mouse vas deferens and its relation to calcium

Naunyn-Schmiedeberg's Archives of Pharmacology
O SouilemA Jondet

Abstract

Isolated mouse vas deferens preparations were used to study the effect of temperature on noradrenaline-induced contractions. Preparations were suspended in the organ bath containing Krebs-Henseleit solution for isometric tension recording. Contractile responses to noradrenaline were investigated in the mouse vas deferens after moderate cooling from 37 to 26 or 22 degrees C. A significant increase of the phasic contractions to noradrenaline was observed at 26 or 22 degrees C compared with responses obtained at 37 degrees C (about 12.3 and 35.6% increase at 26 and 22 degrees C, respectively). The secondary noradrenaline-induced sustained contraction was also significantly enhanced after moderate cooling to 26 degrees C. The potentiation of noradrenaline-induced contraction at 26 degrees C remained in a Ca(2+)-free EGTA (1 mM)-containing solution. However, sustained contraction was suppressed after removal of the calcium from the medium at 37 and 26 degrees C. Contraction to caffeine was significantly enhanced at 22 degrees C compared with 37 degrees C. By contrast, barium chloride-induced contraction of the vas deferens was markedly decreased after moderate cooling to 22 degrees C. In the presence of ouabain (0.1 mM), the noradre...Continue Reading

Citations

Jun 28, 2003·American Journal of Veterinary Research·Mohamed Y MallemJean-Claude Desfontis
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J WingardR A Murphy
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Sugaya, W C de Groat

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