PMID: 11334280May 4, 2001Paper

Effect of moderate hypothermia on experimental severe subarachnoid hemorrhage, as evaluated by apparent diffusion coefficient changes

Neurosurgery
A PiepgrasL Schilling

Abstract

The aims of this study were to investigate the early changes in the mean apparent diffusion coefficient (ADC) after severe subarachnoid hemorrhage (SAH), as a marker of ischemic damage, and to examine the effects of moderate hypothermia, induced at various time points, on ADC changes. ADC maps were calculated from diffusion-weighted, blipped-epi, spin echo, magnetic resonance imaging sequences (2.35-T BIOSPEC 24/40 scanner; Bruker Medizin Technik GmbH, Karlsruhe, Germany) for 21 anesthetized (0.45-1% halothane, temperature-adjusted/30% oxygen/69% nitrogen) and ventilated Wistar rats. After baseline scanning, bolus injection of 0.5 ml of autologous arterial blood or artificial cerebrospinal fluid (control group), into the cisterna magna, was performed. Serial scanning was performed for 3 hours after injection, using normothermic or hypothermic (32 degrees C) rats. In an additional series of experiments, hypothermia was initiated either immediately or 60 minutes after normothermic SAH. The water contents of the removed brains were calculated using the wet/dry weight method. The ADC values did not change in the control group but decreased to 88.6+/-5.2% (P < 0.05 versus baseline) after SAH and remained significantly decreased thro...Continue Reading

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Citations

Jan 14, 2005·The New England Journal of Medicine·Michael M ToddUNKNOWN Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) Investigators
Jun 26, 2009·Critical Care Medicine·Kees H Polderman
May 3, 2003·Intensive Care Medicine·Emanuela KellerYasuhiro Yonekawa
Feb 17, 2009·Journal of Neurotrauma·Crystal L MacLellanFrederick Colbourne
Apr 10, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Jennifer A FronteraErrol Gordon
Dec 17, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lucia Rivera-LaraSusanne Muehlschlegel

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