PMID: 1200990Jun 1, 1975Paper

Effect of modification of thyroid function on cholesterol 7 alpha-hydroxylation in rat liver

The Biochemical Journal
N TakeuchiY Yamamura

Abstract

Hepatic activities of cholesterol synthesis and cholesterol 7 alpha-hydroxylation were determined in hyper- and hypo-thyroid rats after oral administration of glucose or cholesterol. Increases in activities of both cholesterol synthesis and cholesterol 7 alpha-hydroxylation induced by glucose administration were enhanced by pretreatment with thyroid powder but suppressed by pretreatment with thiouracil. The enhancement of 7 alpha-hydroxylation was produced by a relatively small amount of thyroid powder, but high doses were required to increase cholesterol synthesis. On the other hand, the suppression of 7 alpha-hydroxylation was brought about by a low dose of thiouracil, but high doses were required to decrease cholesterol synthesis. Although cholesterol synthesis increased similarly in both hypo- and hyper-thyroid rats after glucose administration, hydroxylase activity in hypothyroid rats began to increase more slowly and was always lower than that in hyperthyroid rats. Thus it is concluded that cholesterol 7 alpha-hydroxylase activity is more sensitive to thyroid function than are activities of cholesterol-synthetic enzymes. When exogenous cholesterol was given, hypothyroid rats showed a larger increase in serum cholesterol c...Continue Reading

Citations

Dec 3, 2003·Journal of Physiology and Biochemistry·T SzkudelskiK Szkudelska
Jul 1, 1990·The British Journal of Nutrition·S NagaokaA Yoshida
Jan 1, 1981·Progress in Lipid Research·F L Hoch
Jan 1, 1988·Progress in Lipid Research·F L Hoch

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