PMID: 11910051Mar 23, 2002Paper

Effect of modified diabetic splenocytes on mice injected with multiple low-dose streptozotocin

Experimental Biology and Medicine
Claudia PastoraleHéctor Chemes

Abstract

This work reports the effects of a previous injection of mitomycin-modified splenocytes from multiple-low dose streptozotocin-treated mice (mld-sz) on autoimmune diabetes produced by mld-sz. Our work shows that a previous inoculation of modified mononuclear splenocytes from mld-sz mice prevents alterations in glycemia, in insulin secretion (IS) pattern from isolated perifused islets, and in mass of pancreatic islets. Immunohistochemistry showed an alteration in the number of beta, but not of alpha or delta cells. While a mononuclear intra-islet infiltration was observed in mld-sz mice, a predominantly polar or peri-islet infiltration was seen in vaccinated mice. Islet-associated mononuclear cells from mld-sz mice produced diabetes and induced a diminished IS when transferred to normal receptors. Those cells from previously vaccinated mld-sz mice had no effect when injected into normal receptors. In addition, they also inhibited the damage induced in normal receptors by the islet-associated mononuclear cells from mld-sz animals. Cellular death was also prevented by previous vaccination. Our results suggest that vaccination with modified splenocytes from mld-sz mice is capable of shifting the islet cells infiltration pattern from...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Papaccio, V Esposito
Mar 1, 1992·Clinical Immunology and Immunopathology·D A HaflerH L Weiner
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S G PaikS I Shin
May 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·M ArataJ C Basabe
May 30, 1998·Diabetes/metabolism Reviews·P Pozzilli
Jul 29, 1998·Diabetes/metabolism Reviews·A Rabinovitch

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Citations

Apr 21, 2005·Pancreas·Liliana M KarabatasJuan C Basabe
Aug 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Irina G DanilovaMusa T Abidov

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