Effect of modified wuzi yanzong granule on patients with mild cognitive impairment from oxidative damage aspect

Chinese Journal of Integrative Medicine
Xue-mei WangJin-xia Yang

Abstract

To observe the effects of modified Wuzi Yanzong Granule (WYG) on memory function and the activity of serum superoxide dismutase (SOD), malondialdehyde (MDA) levels, leukocyte mitochondrial DNA (mtDNA) deletion rate and beta-amyloid protein(1-28) (A beta(1-28)) in patients with mild cognitive impairment (MCI). Thirty-six patients with MCI were selected based on the internationally recognized Petersen's criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A beta(1-28) content were observed before and after treatment. Compared with the normal control group, the memory quotient and SOD activity in patients with MCI decreased significantly (P < 0.01), while MDA, A beta(1-28) levels and the leukocyte mtDNA deletion rate increased significantly (P < 0.01). After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A beta(1-28) level decreased in the treated group compared with th...Continue Reading

References

Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Feb 13, 2003·European Journal of Biochemistry·David FrostAvijit Chakrabartty
Apr 21, 2004·Journal of Alzheimer's Disease : JAD·Patrizia Mecocci

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Citations

Sep 11, 2009·Indian Journal of Psychiatry·Chittaranjan Andrade, Rajiv Radhakrishnan
Nov 22, 2015·Chinese Journal of Integrative Medicine·Yi-Xiang SongWei-Wei Li

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