Effect of molecular structure of poly(glycidyl ether) reagents on crosslinking and mechanical properties of bovine pericardial xenograft materials

Journal of Biomedical Materials Research
J M LeeL W Kan


With the identification of the exacerbating effect of glutaraldehyde on calcification of heart valve materials, there exists a renewed interest in both alternative reagents and the effects of crosslinking on connective tissues. One potentially useful class of reagents are poly(glycidyl ether) compounds. We have examined 5 of these reagents with different molecular sizes and functionalities for their effects on mechanical properties and collagen denaturation (shrinkage) temperature. Samples of bovine pericardium were tested fresh or after 48 h fixation in one of the five compounds for denaturation temperature, stress-strain response, stress relaxation, plastic deformation, and fracture properties. Of the compounds tested, those with intermediate length backbones and 4 or 5 epoxide groups were most effective in producing intrahelical crosslinking and increased denaturation temperature over 48 h. However, in samples examined after 17 months of fixation, all reagents had equivalently increased the denaturation temperature. Examination of mechanical results revealed two distinct mechanisms for mechanical change. Observed shifting of the stress-strain curve to the right (due to shrinkage), increased plastic deformation, and some redu...Continue Reading


Jan 1, 1977·Annual Review of Biochemistry·K Peters, F M Richards
Jan 1, 1975·Biomaterials, Medical Devices, and Artificial Organs·E StrawichM E Nimni
Oct 15, 1992·The Journal of Comparative Neurology·J L Juang, S D Carlson
Sep 1, 1991·The Japanese Journal of Surgery·Y MurayamaT Oka
Feb 1, 1990·Journal of Biomedical Materials Research·H PetiteD Herbage
Sep 1, 1990·Journal of Biomedical Materials Research·L L Huang-LeeM E Nimni
Aug 1, 1989·Matrix : Collagen and Related Research·D SimionescuN A Kefalides
Sep 1, 1988·The Annals of Thoracic Surgery·I VeselyT Song
Feb 29, 1988·Biochemical and Biophysical Research Communications·D SimionescuN A Kefalides
Apr 1, 1985·The Histochemical Journal·D Hopwood
Apr 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Hassell, A R Hand
Sep 1, 1984·Journal of Biomedical Materials Research·E GendlerM E Nimni
Jan 1, 1983·Biomaterials, Medical Devices, and Artificial Organs·K WeadockF H Silver
Jan 1, 1984·Connective Tissue Research·J G GavilanesN Olmo
Oct 1, 1983·Journal of Dental Research·D M Ranly, E P Lazzari
Sep 1, 1980·Progress in Cardiovascular Diseases·W W Angell, J D Angell
Jan 1, 1993·Journal of Biomedical Materials Research·R TuR C Quijano

❮ Previous
Next ❯


Oct 1, 1996·Journal of Biomedical Materials Research·M A MooreB K McIlroy
Jul 9, 1999·Journal of Biomedical Materials Research·R ZeemanJ Feijen
Jul 6, 2000·Journal of Biomedical Materials Research·R ZeemanJ Feijen
Jul 26, 2002·Clinical Neurology and Neurosurgery·A BaharuddinJ Abdullah
Jul 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·N R VyavahareR J Levy
Mar 27, 2015·Drug Delivery and Translational Research·Jiseung HeoNathaniel S Hwang
May 13, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Salma ChaudhuryAndrew J Carr
Jan 1, 2011·Journal of Functional Biomaterials·Valérie SamouillanColette Lacabanne
Jan 11, 2003·Journal of Biomedical Materials Research. Part a·V SamouillanM Moore
Jun 15, 2015·Journal of Applied Polymer Science·Andrew C WeemsDuncan J Maitland
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paul F GratzerJ Michael Lee
May 26, 1999·Journal of Biomaterials Applications·J M García Páez, E Jorge-Herrero
Mar 31, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ian G AldousJ Michael Lee
Oct 21, 2015·Bio-medical Materials and Engineering·Xiaotong WangJiang Chang
Jul 9, 1999·Journal of Biomedical Materials Research·P ZiouposA J Hamer
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess
Sep 17, 2009·Bioconjugate Chemistry·Benedict Law, Ching-Hsuan Tung

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.