PMID: 15348393Sep 7, 2004Paper

Effect of molecular weight and concentration of poly(acrylic acid) on the formation of a polymeric calcium phosphate cement

Journal of Materials Science. Materials in Medicine
A O MajekodunmiJ W Nicholson

Abstract

Previous investigations have noted that the tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) apatite forming calcium phosphate cement (CPC) possesses many favorable properties from a biomaterials standpoint. Despite these positive properties various shortcomings have limited clinical usage of these materials and fostered investigations into the effect of numerous additives. The present study concerns the effect of poly(acrylic acid) (PAA) addition and the influence of factors such as molecular weight and concentration of the additive on the properties of the set cement. One-way ANOVA was conducted using all results obtained, to firstly derive the influence of concentration within each molecular weight group, and secondly to derive the influence of molecular weight within each concentration group. All investigated mechanical properties were influenced by both molecular weight and concentration of the additive. Higher molecular weights tended to result in cements with shorter setting times and higher compressive, diametral and biaxial flexural strengths than their lower molecular weight counterparts. The effect of concentration on the properties of the set cement however was somewhat more complex, a negative cor...Continue Reading

Citations

Apr 28, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Faleh Tamimi MariñoEnrique López Cabarcos
Apr 19, 2012·Journal of Tissue Engineering·Roman A PerezMaria-Pau Ginebra
Jan 1, 2013·Journal of Functional Biomaterials·Sergey V Dorozhkin
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·Daniel L Alge, Tien-Min Gabriel Chu

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