Effect of molecular weight on the diffusion of contrast media into cartilage

Spine
T J PerlewitzV George

Abstract

A comparison of contrast enhancement in the intervertebral disc from two magnetic resonance imaging contrast media in experimental animals. To test the effect of molecular weight on the diffusion of ionic contrast media into the intervertebral disc. Intravenously administered gadopentetate diffuses similarly into the fibrocartilage of intervertebral discs and herniated disc fragments. Differentiation between recurrent disc fragments and scar tissue via magnetic resonance imaging is optimized by using contrast media, which result in different contrast enhancement of these two tissues. Contrast media of higher molecular weight diffuse more slowly into cartilage; hypothetically, therefore, such media will produce better contrast between scar tissue and recurrent disc fragments. Gadopentetate (molecular weight 546) or gadolinium-polylysine (molecular weight 40,000) was injected intravenously into rabbits. The signal intensities of intervertebral disc and muscle tissue were recorded by magnetic resonance imaging at baseline and at pre-determined intervals for 2 hours after injection of the contrast medium. Contrast enhancement in these tissues was calculated in each animal for each contrast medium, and differences in enhancement wer...Continue Reading

Citations

Nov 27, 2004·Spine·Jill P G UrbanJeremy C T Fairbank
Jan 1, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S MotaghinasabJ P G Urban
Sep 22, 2007·Radiology·Michael T Modic, Jeffrey S Ross
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·S RajasekaranSubramaniam Murugan
Aug 25, 2006·Journal of Magnetic Resonance Imaging : JMRI·Jaakko L NiinimäkiMiika T Nieminen
Apr 27, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michiel SiebeltHarrie Weinans
Mar 18, 2008·Osteoarthritis and Cartilage·T M PiscaerH Weinans
Aug 19, 2016·Radiological Physics and Technology·Bimali Sanjeevani Weerakoon, Toshiaki Osuga
Apr 6, 2006·The Journal of Bone and Joint Surgery. American Volume·Thijs GrunhagenJill P G Urban
Apr 6, 2006·The Journal of Bone and Joint Surgery. American Volume·Victor Haughton

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