PMID: 8966309Sep 1, 1996Paper

Effect of Momordica charantia L. in mice infected with Plasmodium berghei

Revista Da Sociedade Brasileira De Medicina Tropical
H M UenoE Salata

Abstract

According to the World Health Organization malaria is one of the major public health problems in Brazil and all over developing countries, where 80% of the population use traditional medicine to solve their primary medical problems. Both treatment and control of this parasitosis have become difficult, because of parasite strains that are resistant to conventional drugs, such as chloroquine. That makes the search for new antimalarial drugs not only important but urgent. We aimed therefore at evaluating the effects of Momordica charantia L. (Cucurbitaceae) in mice infected with Plasmodium berghei. We used aquose and ethanotic extracts in a dose of 1000 mg/kg of body weight, orally, for five consecutive days (i.e. from day 2 to day 6 postinfection). We then followed up the parasitaemia during the course of infection. Although the population use this plant as an antimalarial, in our experimental conditions, M. charantia extracts have not shown such activity.

References

Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·G J SchuurkampK H Rieckmann
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·P L Garavelli, E Corti
Jan 1, 1991·Memórias do Instituto Oswaldo Cruz·C Z AmorimR S Cordeiro
Jan 1, 1991·Memórias do Instituto Oswaldo Cruz·L H Carvalho, A U Krettli
Jan 1, 1991·The American Journal of Tropical Medicine and Hygiene·C J FontesA U Krettli
Jan 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene· Pe Than Myint Win Myint
Sep 1, 1988·Journal of Ethnopharmacology·C Z AmorimR S Cordeiro
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·A N ChawiraW Peters
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene· Pe Than Myint, Tin Shwe
Nov 1, 1987·Revista Do Instituto De Medicina Tropical De São Paulo·M A SantosV E Rosário
Jul 1, 1986·Journal of Ethnopharmacology·M O Abatan, M J Makinde
May 1, 1981·The American Journal of Tropical Medicine and Hygiene·J J FerraroniM Suzuki
Jun 1, 1993·Annals of Tropical Medicine and Parasitology·J A FreeseM B Markus
Sep 1, 1993·The American Journal of Tropical Medicine and Hygiene·L K Basco, J Le Bras
Jul 1, 1993·The American Journal of Tropical Medicine and Hygiene·B A Gingras, J B Jensen
Jun 1, 1987·Parasitology Today·A Cruz Marques

❮ Previous
Next ❯

Citations

Jan 22, 2005·Fundamental & Clinical Pharmacology·Mohamad Fawzi MahomoodallyAnwar Hussein Subratty
Jan 1, 2008·Journal of Dietary Supplements·Lana Dvorkin-Camiel, Julia S Whelan
Jun 9, 2004·Journal of Ethnopharmacology·J K Grover, S P Yadav

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.