Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
A MazzaDomenico Rubello

Abstract

Metabolic syndrome (MetS) is a world-wide epidemic disease with an increased risk of morbidity and mortality. Treatment strategies of MetS include pharmacologic and non-pharmacologic interventions and in this respect a relevant role has been shown for nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs incorporated with diet and lifestyle management versus diet alone, in lowering blood pressure (BP) values and improving lipid and glucose profile, in a group of hypertensives and hyper-cholesterolemic patients with MetS. 104 subjects with MetS (mean age 57.4 ± 8.8 years, 51% males) without history of cardio-vascular (CV) diseases were enrolled in the study. 52 subjects were treated with a once-daily oral formulation of a NCs containing red yeast rice and coenzyme Q10 added to their diet for 2 months and were compared with the 52 patients following a diet program. Differences in BP, serum total cholesterol (TC), low- and high-density-lipoprotein cholesterol (LDLC and HDLC), triglycerides (TG) and glucose values were compared by analysis of variance. A significant reduction of BP, TC, TG, LDLC and glucose levels was observed in both treatment groups. However, a greater reduction of...Continue Reading

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Citations

May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiawen SongXiaofang Li
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marilyn K Schoenle, Stephanie L Ballard
Jun 3, 2021·Antioxidants·Yoana Rabanal-RuizFrancisco Javier Alcain
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chien-Hui WuGuo-Jane Tsai
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jia-Yue DuanLing-Qing Yuan

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