Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice.

Journal of Cardiovascular Disease Research
Kuldip Singh, P Ahluwalia

Abstract

Monosodium glutamate (MSG), a sodium salt of glutamic acid is commonly used as flavor enhancer in Chinese, Japanese and ready to serve foods all over the World, is the inducer of oxidative stress. In the present era, MSG and alcohol is becoming a part of daily food. Concomitantly, there is a tremendous increase in the incidences of cardiovascular diseases. So, the present study was designed to elucidate the effect of MSG by evaluating the changes in oxidative stress markers in cardiac tissue of normal and alcoholic adult male mice. Animals were divided into six groups of six mice each and MSG at dose levels of 0, 4, and 8 mg/g body weight was given orally for seven consecutive days (that is from 31st day to 37(th) day of alcohol ingestion) to chronic alcoholic (30% ethanol/100 g body weight) adult male mice. After the dose period (38(th) day), animals were fasted overnight, sacrificed by decapitation and hearts were removed for the estimation of lipid peroxidation (LPO), xanthine oxidase (XOD), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) and its metabolizing enzymes like glutathione peroxidase (GPx) and glutathione reductase (GR). A significant (P < 0.001) increase was observed in LPO and XOD levels while a...Continue Reading

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Citations

May 16, 2012·Biological Trace Element Research·Zi-wei ZhangShi-wen Xu
Apr 6, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lian-Yun ChenShi-Zhong Zheng
Jun 21, 2013·American Journal of Therapeutics·Zafar H Israili
Mar 22, 2016·Environmental Science and Pollution Research International·Sarwat JahanNaveed Rauf
Apr 3, 2020·Environmental Science and Pollution Research International·Suzan M HazzaaGhada E Elgarawany
May 31, 2019·BMJ : British Medical Journal·Bernard SrourMathilde Touvier
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Márcio CarochoIsabel C F R Ferreira
May 24, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Octavia-Laura MoldovanCamil-Eugen Vari
Oct 14, 2021·Current Gastroenterology Reports·Osman Mohamed ElfadilManpreet S Mundi

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