Effect of morphine on dynorphin B and GABA release in the basal ganglia of rats

Brain Research
Z B YouL Terenius

Abstract

In vivo microdialysis was used to study the effects of systemic, as well as intracerebral administration of morphine and naloxone on dynorphin B release in neostriatum and substantia nigra of rats. The release of dopamine (DA), gamma-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) was also investigated. Systemic injection of morphine (1 mg/kg s.c.) induced long-lasting increases in extracellular dynorphin B and GABA levels in the substantia nigra, whereas DA, Glu and Asp levels, measured in the same region, were not significantly affected. No effect on striatal neurotransmitter levels was observed following systemic morphine administration. Local perfusion of the substantia nigra with morphine (100 microM) through the microdialysis probe also increased nigral dynorphin B and GABA levels. Perfusion of the neostriatum with morphine (100 microM) significantly increased GABA and dynorphin B levels in the ipsilateral substantia nigra, but no effect was observed locally. Naloxone blocked the effect of systemic morphine administration on nigral dynorphin B and GABA release, already at a dose of 0.2 mg/kg s.c. Naloxone alone, given either systemically (0.2-4 mg/kg s.c.) or intracerebrally (1-100 microM), did not affect dy...Continue Reading

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Citations

Aug 23, 2003·Brain Research·Scott M RawlsAlan Cowan
Nov 11, 1999·European Journal of Pharmacology·I M Maisonneuve, S D Glick
Aug 1, 1997·Natural Product Reports·K W Bentley
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Nov 24, 2020·Pharmacology, Biochemistry, and Behavior·Ewa Galaj, Zheng-Xiong Xi

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