Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism

Peptides
Luo XuT L Peeters

Abstract

The study aims to find the effect of motilin on neuronal activity of gastric distension-responsive neurons in rat hippocampus and its possible mechanism. Single unit discharges in the hippocampal CA1 region were recorded extracellularly by means of four-barrel glass micropipettes in anesthetized rats and the expression of nNOS in hippocampus was observed by fluo-immunohistochemistry staining. Of the 171 recorded neurons, 76.0% were GD-excitatory (GD-E) neurons and 24.0% were GD-inhibited (GD-I) neurons. The 57.6% of GD-E neurons showed an excitatory response to motilin and the same effect was observed in 51.7% GD-I neurons. However, when NOS inhibitor nitro-l-arginine methyl ester (l-NAME) was administrated previously, the followed motilin-induced excitatory responsiveness of GD-responsive neurons was reduced. In contrast, discharge activity of GD-responsive neurons with motilin was enhanced by pretreatment of NO precursor l-arginine. The expression of nNOS-IR positive neurons was significantly increased in CA1 after administration of motilin. Our findings suggested that motilin excited the GD-responsive neurons in the hippocampal CA1 region and the excitatory effect of motilin may be mediated by the endogenous NO.

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Citations

Jan 12, 2013·Molecular Neurobiology·Bin FengMing-Gao Zhao
Oct 9, 2013·General and Comparative Endocrinology·Yanling GongShengli Gao
May 3, 2011·Trends in Pharmacological Sciences·Gareth J SangerPaul L R Andrews
Feb 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L XuX Sun

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