Effect of moxibustion at "Shenque" (CV8) and "Zusanli" (ST36) on expression of adiponectin and adiponectin receptor in Alzheimer's disease rats

Zhen ci yan jiu = Acupuncture research
Cai-Jiao ZhaoMei-Jing Lu

Abstract

To observe the effect of moxibustion on serum adiponectin content, and expression of adiponectin and adiponectin receptor in adipose tissue in Alzheimer's disease (AD) rats, so as to explore its mechanism underlying improvement of AD. Fifty male SD rats were randomly divided into control, model, Shenque (CV8), Zusanli (ST36) and CV8+ST36 groups (n=10 in each group). The AD model was established by intraperitoneal injection of D-galactose (400 mg•kg-1•d-1) for 5 weeks and scopolamine hydrobromide (3 mg •kg-1•d-1) for 2 weeks. Moxibustion was applied to CV8, ST36 and CV8+ST36 respectively for 3 moxa-cones every time, once daily for 5 weeks. Morris water maze tests were used to assess the rats' learning-memory ability. The contents of serum adiponectin were assayed using ELISA, and the expression of adiponectin and adiponectin receptor in the adipose tissue was detected by quantitative real-time PCR and Western blot, separately. Following modeling, the average escape latency of Morris water maze tests was significantly prolonged (P<0.05), the content of serum adiponectin and the expression level of adiponectin mRNA in adipose tissue were significantly decreased (P<0.01), the expression of adiponectin receptor protein significantly...Continue Reading

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