Effect of moxifloxacin on secretion of cytokines by human monocytes stimulated with lipopolysaccharide

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
F G AraujoJ S Remington

Abstract

To determine the effect of moxifloxacin on secretion of cytokines by human monocytes stimulated with lipopolysaccharide (LPS) or Pansorbin. Monocytes obtained from 10 healthy volunteer donors were stimulated with LPS or Pansorbin and exposed or not to different concentrations of the fluoroquinolone antibiotic moxifloxacin. At 3, 6 and 24 h, the amounts of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, IL-12 (p70) and tumour necrosis factor-alpha (TNF-alpha) were measured in the supernatants of the monocyte cultures using enzyme-linked immunosorbent assay. Stimulation of human monocytes with either LPS or Pansorbin resulted in a significant increase in secretion of each of the cytokines examined. Treatment of LPS-stimulated monocytes with moxifloxacin significantly inhibited (P < 0.01) secretion of IL-1alpha by monocytes of each of 10 human donors; the secretion of TNF-alpha was significantly inhibited (P < 0.01) in monocytes from six of 10 donors. In general there was a trend towards inhibition of secretion of IL-6, IL-10 and IL-12 (p70), but the inhibitory effect was not statistically significant. Secretion of cytokines by Pansorbin-stimulated monocytes was not significantly inhibited by moxifloxacin. Moxifloxacin has ...Continue Reading

References

Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Jul 1, 1996·Infection·B Van VlemS Ringoir
Jul 14, 1998·Antimicrobial Agents and Chemotherapy·A A KhanJ S Remington
Dec 30, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M OpalP Grint
Apr 30, 1999·International Journal of Antimicrobial Agents·A A KhanJ S Remington
Jul 7, 2000·The Journal of Infectious Diseases·A A KhanJ S Remington
Oct 13, 2006·Current Opinion in Infectious Diseases·M T Labro

❮ Previous
Next ❯

Citations

Jun 5, 2003·The Lancet Infectious Diseases·Axel Dalhoff, Itamar Shalit
Apr 27, 2007·Southern Medical Journal·Mesut Ogrendik
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Heng-Ching HuangYin-Ching Chuang
Oct 18, 2006·Antimicrobial Agents and Chemotherapy·Koh TakeyamaYoshio Kuroki
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Jung-Hyun ChoiWan-Shik Shin
Jul 9, 2010·Clinical Microbiology Reviews·Soichiro Kanoh, Bruce K Rubin
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathryn ChmuraEdward D Chan
Sep 10, 2013·PloS One·Claudia MancaSelvakumar Subbian
Apr 28, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiromi OginoSeiji Hori
Nov 8, 2008·Diagnostic Microbiology and Infectious Disease·Evangelos J Giamarellos-BourboulisKyriaki Kanellakopoulou
Jan 25, 2006·Journal of Dermatological Science·Koji MurataYoshiki Tokura
Feb 14, 2003·Journal of Chemotherapy·C GrassiUNKNOWN SMART Study Group. Studio Multicentrico con Moxifloxacina nel Trattamento delle Riacutizzazioni de Bronchite Cronica
Mar 8, 2005·The Journal of Veterinary Medical Science·Raadan OdbilegMisao Onuma
Nov 20, 2014·The Journal of Antimicrobial Chemotherapy·H C Müller-RedetzkyM Witzenrath
Jan 13, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Hannelore BellonGeert M Verleden
Mar 11, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F AraujoJ Remington
Oct 6, 2017·Ocular Immunology and Inflammation·Ki Yup NamJung Yeul Kim
Jul 19, 2014·Respiratory Research·Christoph BeisswengerRobert Bals
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Holger Müller-RedetzkyMartin Witzenrath
May 5, 2017·Frontiers in Immunology·Ira EkmekciuMarkus M Heimesaat
Jan 27, 2017·Drug and Chemical Toxicology·Małgorzata Pomorska-MólZygmunt Pejsak
Mar 5, 2019·Chemical Research in Toxicology·Seyyede Araste Aldaghi, Razieh Jalal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.