Effect of mu-opioids morphine and buprenorphine on the development of adjuvant arthritis in rats

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
J S WalkerR O Day

Abstract

On the basis that endogenous opioids play a role in the physiological response to inflammation, this study tests the anti-arthritic effects of a mu-opioid agonist, morphine and the partial mu-agonist, buprenorphine. Male Lewis rats were used. Rats were inoculated subcutaneously with 0.05 ml of Freund's complete adjuvant (5 mg/ml) into the right hind paw to produce adjuvant arthritis. Morphine (either 10 to 60 mg/kg/day s.c. bolus or 60 mg/kg/day s.c. infusion) and buprenorphine (0.65 +/- 0.06 mg/kg/day, orally), respectively, were administered for 3 days during the primary inflammatory phase of adjuvant arthritis. The progression of adjuvant arthritis was monitored every three days by body weight change and hind limb oedema (ipsilateral and contralateral). On day 21 the animals were sacrificed and histology and radiography of the contralateral limb were performed. In rats receiving Freund's adjuvant and no drug treatment, the incidence of arthritis was 89%. Effect was expressed as the pooled severity index (PSI) derived from the arithmetic average of the volume, histology and radiography scores in the contralateral hind limb. Buprenorphine had no effect on experimental arthritis (PSI control vs treated: 242 +/- 28 vs 253 +/- 28...Continue Reading

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Citations

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Dec 13, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason J McDougallChelsea M McDougall
May 27, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·David S Jessop
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Aug 5, 1998·British Journal of Pharmacology·W Binder, J S Walker
Aug 29, 2021·Viruses·Germán Gustavo GornalusseFlorian Hladik

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