PMID: 9650537Jul 3, 1998Paper

Effect of multiple doses of rifampin on the [14C N-methyl] erythromycin breath test in healthy male volunteers

Journal of Clinical Pharmacology
M N GharaibehS A Waldman

Abstract

The erythromycin breath test (EBT), which measures 14CO2 produced from [14C N-methyl] erythromycin, is one of the most frequently employed measures to examine drug interactions involving cytochrome P450 3A4 (CYP3A). However, the reproducibility and reliability of this test, and the effects of drugs that alter CYP3A activity, continue to be defined. In this study, the reproducibility of the EBT was evaluated in eight healthy volunteers before and after oral administration of 600 mg of rifampin daily for 8 days. Two sequential EBT determinations performed 5 days apart before rifampin administration were highly reproducible. Rifampin induced CYP3A, reflected in a mean percent (+/- standard deviation) increase in EBT values of 86 +/- 30%. Recovery of enzyme function after discontinuation of rifampin for 17 days was manifested as a return of EBT values to preinduction levels. These results support the utility of EBT as a valid, reproducible, and reliable measure of CYP3A activity in vivo.

References

Dec 1, 1992·Trends in Pharmacological Sciences·S CholertonJ R Idle
Nov 1, 1992·Clinical Pharmacology and Therapeutics·D K TurgeonP B Watkins
Nov 1, 1992·The Journal of Clinical Investigation·J C KolarsP B Watkins
Sep 1, 1992·Trends in Pharmacological Sciences·F J Gonzalez
Jan 1, 1992·Clinical Pharmacokinetics·K Venkatesan
Jun 1, 1992·Mechanisms of Ageing and Development·C M HuntJ A Wilson
Jan 11, 1992·Clinical Pharmacology and Therapeutics·C M HuntP S Guzelian
Jan 1, 1991·Methods in Enzymology·P B Watkins
Aug 1, 1990·Clinical Pharmacology and Therapeutics·P B WatkinsJ J Voorhees
Jan 1, 1989·European Journal of Clinical Pharmacology·E E OhnhausB K Park
Jan 1, 1981·Clinical Pharmacokinetics·B K Park, A M Breckenridge
Sep 1, 1980·British Journal of Clinical Pharmacology·K L AustinP J McDonald
Jan 1, 1995·Clinical Pharmacology and Therapeutics·K S LownP B Watkins
Aug 1, 1994·Pharmacogenetics·P B Watkins
Oct 1, 1995·British Journal of Clinical Pharmacology·T TateishiA J Wood
May 1, 1997·Clinical Pharmacology and Therapeutics·C L ChengP L Stetson

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Citations

Oct 9, 2007·Cancer Chemotherapy and Pharmacology·Paul R HutsonGeorge Wilding
Jul 23, 2013·Clinical Pharmacokinetics·Frans L OpdamHenk-Jan Guchelaar
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Henry M BlumbergUNKNOWN American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society
May 1, 2001·Clinical Pharmacokinetics·L P RivoryS J Clarke
Jul 4, 2001·Clinical Pharmacokinetics·W J BurmanC Peloquin
Jul 29, 2003·Clinical Pharmacokinetics·Mikko NiemiKari T Kivistö
Mar 17, 2007·Drug Metabolism Reviews·Miki Katoh, Tsuyoshi Yokoi
Jun 28, 2007·Journal of Herbal Pharmacotherapy·Jean Paul A NicandroB Joseph Guglielmo
Jul 18, 2006·British Journal of Clinical Pharmacology·Stéphane MoulyJean-François Bergmann
Nov 26, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M KatohT Yokoi
Sep 5, 2003·Journal of Clinical Pharmacology·Maria L VeroneseHoward E Greenberg
Oct 1, 2003·Journal of Clinical Pharmacology·Maria L VeroneseHoward E Greenberg
May 30, 2008·Clinical Pharmacology and Therapeutics·R M FrankeA Sparreboom
Nov 25, 2005·Pharmacotherapy·Rolf P G van HeeswijkEd Mills
May 21, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Patrick J RobertsRoy L Hawke
Feb 13, 2001·Antimicrobial Agents and Chemotherapy·R E PolkD S Stein
Nov 7, 2020·Journal of Veterinary Pharmacology and Therapeutics·Hande Sultan Şahiner, Cavit Kum

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