PMID: 2510159Oct 1, 1989Paper

Effect of multiple interferon gamma injections on the disposal of Mycobacterium leprae

Proceedings of the National Academy of Sciences of the United States of America
G KaplanZ A Cohn

Abstract

The effect of multiple intradermal injections (four to six) of 10 micrograms of interferon gamma on the number of Mycobacterium leprae in the skin of patients with polar lepromatous leprosy and borderline lepromatous leprosy was evaluated. To achieve a maximum zone of induration and cell emigration a preparatory dose of the lymphokine was required. A second group of three injections, given 3-4 days after the initial series, resulted in lesser degrees of induration and was more in keeping with a partial local hyporesponsive state. A marked emigration of T cells and monocytes into the dermis resulted from injections of interferon gamma and persisted for greater than 21 days. A preponderance of CD4+ cells in the infiltrate was seen within a few days and CD4/CD8 ratios remained elevated for greater than 5 weeks. The bacillary load of injected sites evaluated 21 days after lymphokine administration was reduced in 14/17 patients by factors ranging from 5- to 1000-fold. This occurred predominantly within diffuse lesions and occurred rarely in nodular sites. Biopsy samples of injected sites taken 6 months later demonstrated progressive 10-fold reductions in bacilli and the continued presence of a granulomatous response.

References

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G KaplanZ A Cohn
Jun 9, 1988·The New England Journal of Medicine·H W MurrayM S Hirsch
Mar 1, 1987·The Journal of Experimental Medicine·G KaplanZ A Cohn
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Oct 1, 1983·The Journal of Experimental Medicine·G KaplanZ A Cohn
Mar 1, 1984·The Journal of Experimental Medicine·M A HorwitzZ A Cohn
Dec 1, 1983·The Journal of Experimental Medicine·N NogueiraR Steinman
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L EvansR A Good
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E G EnglemanR Levy

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Citations

Sep 1, 1990·Diagnostic Microbiology and Infectious Disease·J L KrahenbuhlG T Chae
Feb 1, 1991·Current Opinion in Immunology·G Kaplan, Z A Cohn
Feb 1, 1992·Bio/technology·G KaplanK A Smith
May 19, 1998·Nature Medicine·I Nath
May 2, 2002·Clinical and Experimental Immunology·S BrahmbhattH M Dockrell
Jan 1, 1994·The Journal of Experimental Medicine·R M Steinman, C L Moberg
Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C W Czarniecki, G Sonnenfeld
Apr 15, 2006·Clinical Microbiology Reviews·D M ScollardD L Williams
Jan 22, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Mihai G NeteaJos W M Van der Meer
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·F S DhabharB S McEwen
Nov 30, 2014·Clinics in Dermatology·Indira NathVijaya Lakshmi Valluri
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z XingS K Sharma
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deanna A HaggeLinda B Adams
Oct 1, 1996·Infection and Immunity·H M DockrellR Hussain

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