PMID: 6407236Feb 1, 1983Paper

Effect of multiresistance on the minimal inhibitory concentration of N-formimidoyl thienamycin and 6 comparing substances against P. aeruginosa and 4 Enterobacteriaceae species

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
G SchröterI Strenzel

Abstract

The minimal inhibitory concentrations (MICs) of multiresistant strains of P. aeruginosa and four species of Enterobacteriaceae were compared with those of more sensitive ones in N-f-thienamycin and six other antibiotics. The greatest difference between these two differently resistant bacterial populations was found in cefoperazone and the beta-lactamase-instable piperacillin. The latter was used for comparison purposes. The activity of cefsulodin was distinctly reduced in multiresistant strains of P. aeruginosa. Cefotaxime and lamoxactam displayed slightly elevated MICs in multiresistant strains. In N-f-thienamycin a significant difference between the multiresistant and the more sensitive population could not be verified (p greater than 0.05). In this regard it resembles fosfomycin. beta-lactam antibiotics could be ranked by means of correlation analysis of their MICs. Using piperacillin as a reference antibiotic the following order of succession could be arranged according to correlation coefficients in P. aeruginosa: cefoperazone, cefsulodin, lamoxactam, cefotaxime and N-f-thienamycin. For the Enterobacteriaceae species some antibiotics could not be evaluated in this test. Moreover, it was recognized that there was an obvious...Continue Reading

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