Effect of multisite radiofrequency ablation on porcine renal function

Journal of Endourology
David A DucheneJeffrey A Cadeddu

Abstract

The acute and long-term effects of radiofrequency ablation (RFA) on kidney function have not been well studied. The functional change when RFA is used in combination with renal ischemia is likewise unknown. Our goal was to determine the change in renal function caused by various volumes of RFA on a porcine kidney model and the effect cold ischemia had on the results. Twenty-two female pigs with solitary kidneys underwent various volumes of RFA both with and without cold ischemia. Animals were divided into control, 10%, 15%, and 20% ablation of the total kidney volume. Measurements of creatinine were obtained for 2 weeks. In the nonischemic group, the mean acute (day 1-3) creatinine changes in control, 10%, 15%, and 20% ablations were 0.6, 2.4, 1.7, and 2.6 mg/dL, respectively. In the cold-ischemia group, the mean acute creatinine changes were 0.85, 2.33, 3.3, and 3.75 mg/dL, respectively. Regression line analysis demonstrated a positive linear relationship in both groups. Fourteen-day mean creatinine changes for the nonischemic group were similar to those in the control animals and did not show a correlation with ablation volume. The mean creatinine changes at 14 days in the cold-ischemia group showed a positive linear correlat...Continue Reading

References

Oct 10, 1991·The New England Journal of Medicine·A C NovickR R Tubbs
Dec 1, 1967·British Journal of Urology·J E WickhamA M Joekes
Nov 19, 2003·Journal of Endourology·D Brooke Johnson, Jeffrey A Cadeddu
Dec 5, 2003·Clinical Radiology·K-W LuiP R Mueller

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