Effect of mupirocin decolonization on subsequent methicillin-resistant Staphylococcus aureus infection in infants in neonatal intensive care units

The Pediatric Infectious Disease Journal
Yhu-Chering HuangTzou-Yien Lin

Abstract

To evaluate whether topical mupirocin treatment can effectively decolonize methicillin-resistant Staphylococcus aureus (MRSA) carriage and reduce subsequent MRSA infection in neonates. During a 1-year period, the infants admitted to our neonatal intensive care units (NICUs)-1 and NICU-2 were included, and specimens from the nares and umbilicus were obtained within 24 hours, and specimen collection was repeated weekly for 2 weeks. Mupirocin was administered for 5 days to the infants with MRSA colonization in NICU-1 during the first half of the year and then switched to those in NICU-2 during the second half of the year. A total of 525 infants were recruited: 257 infants in the treatment group and 268 in the control group. MRSA colonization was detected in 130 infants (25%) during NICU stay, which is a similar rate in both groups. Twenty-two (4.2%) episodes of MRSA infection were identified. The rate of MRSA infection was significantly higher in infants with prior colonization than in those without (10.2% vs. 2.3%, P<0.001). Among the infants with prior colonization, the rate of MRSA infection in the treatment group was significantly lower than that in the control group (3.2% vs. 16%, P=0.014), and the rate in the treatment group...Continue Reading

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Citations

Oct 28, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rajeshwari NairMarin L Schweizer
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Jun 6, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Rebecca PierceAaron M Milstone
Apr 29, 2015·Current Opinion in Infectious Diseases·Stefania Vergnano
Apr 13, 2021·Microbial Genomics·Yhu-Chering HuangTsai-Ling Yang Lauderdale
Aug 4, 2016·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Sandra L Smith, Laura Serke

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