PMID: 2105915Jan 1, 1990Paper

Effect of murine recombinant interferon-gamma in the protection of mice against Salmonella

International Journal of Immunopharmacology
H MatsumuraM Nakano

Abstract

The ability of recombinant murine (rMu) interferon (IFN)-gamma to activate anti-Salmonella-activity in normal mice and beige mutant (bg/bg) mice with Chediak-Higashi syndrome (CHS) was examined. Previous intraperitoneal (i.p.) injection of rMuIFN-gamma (10(4) U per mouse) significantly hindered the bacterial growth in the peritoneal cavities, spleens and livers of the mice after the i.p. infection with Salmonella enteritidis No. 11 strain. It was also effective on the beige mice that have phagocytic cells with a genetically impaired bactericidal function, suggesting that IFN-gamma activates the pathway irrelevant to the beige mutation. The effect was the maximum, when IFN-gamma was given 6 h before the challenge. The effect seemed to be due to the augmentation of bactericidal capacity rather than the prevention of systemic spread of bacteria. Recombinant human IFN-alphaA/D (10(2)-10(6) U per mouse), which produced effects identical to those of murine IFN-beta, did not show such a bactericidal effect. Bactericidal activity enhancement was also seen in mice that had been injected with a small amount of rMuIFN-gamma (10(2) U) and bacterial lipopolysaccharide (LPS) (10 ng) together at 6 h before the challenge, although the IFN-gamm...Continue Reading

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Citations

Jan 1, 1996·Biotherapy·M Degré
Sep 1, 1993·Agents and Actions·S HockertzT Schettler
Aug 1, 1993·International Journal of Immunopharmacology·K OnozukaM Nakano
Jan 5, 2002·Microbes and Infection·L Eckmann, M F Kagnoff
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C K EdwardsK W Kelley
Jun 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Degré
Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C W Czarniecki, G Sonnenfeld
Aug 25, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Miroslav PruchaStefan Russwurm
Mar 26, 2002·Immunity·Eric A Hughes, Jorge E Galán
Jun 27, 2008·European Journal of Immunology·Manfred NairzGünter Weiss
Jul 8, 1999·The International Journal of Neuroscience·M P Kelley, P Bakan
Jul 1, 1991·Infection and Immunity·M T Cantorna, E Balish

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