PMID: 8457383Feb 1, 1993Paper

Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage

AIDS Research and Human Retroviruses
T F SchulzR A Weiss

Abstract

It has been suggested that the V3 domain of human immunodeficiency virus type 1 (HIV-1) isolates has to interact with a cell-surface-associated or endosomal proteinase during virus entry into susceptible cells. To investigate this hypothesis, we examined the effect of several mutations in the V3 loop on its susceptibility to proteolytic cleavage by thrombin and cathepsin E and compared it with the effect of these mutations on viral infectivity. The data obtained indicate that, if an interaction between the V3 loop and a proteinase is indeed crucial for viral entry, the substrate requirements for such a proteinase(s) would have to be very complex. In particular, it seems unlikely that a single enzyme with a unique specificity would be able to interact with all of the different HIV-1 and HIV-2/SIV strains isolated so far. Therefore, one would have to postulate the involvement of several cellular proteinases, or proteases with multiple specificities, in V3-based viral tropism.

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Citations

Mar 1, 1995·Journal of Peptide Science : an Official Publication of the European Peptide Society·H C BorbeS Modrow
Apr 15, 2008·Protein Expression and Purification·Sean X DuRobert G Whalen
Sep 25, 2002·Clinics in Laboratory Medicine·Monique R FergusonWilliam A O'Brien
Jan 5, 2010·Biochemical and Biophysical Research Communications·De-Chun ChengFeng-Min Zhang
Dec 20, 2003·Nature Reviews. Neuroscience·Farshid NoorbakhshChristopher Power
Oct 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P ClaphamR Weiss
Jan 1, 1997·Journal of Biomedical Science·H.B. Rasmussen
Mar 27, 1998·The Journal of Peptide Research : Official Journal of the American Peptide Society·M DettinC Di Bello
Feb 1, 1997·Journal of Dental Research·N ShineN Düzgüneş
Dec 16, 1998·Journal of Peptide Science : an Official Publication of the European Peptide Society·M DettinC Di Bello
Sep 20, 1996·Science·R A Weiss
May 20, 1994·Science·C PatienceT F Schulz

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