Effect of mycotoxins on some activities of isolated human neutrophils

Immunopharmacology and Immunotoxicology
Adriana RichettiVincenzo Fimiani


Activities of mycotoxins--citrinin, ochratoxin B, rubratoxin B, and zearalenol beta--that affected superoxide anion (O2-) production were studied on human neutrophils with regard to hypochlorous acid (HOCl) generation, nitric oxide (NO) formation, and chemotaxis of isolated cells. At the doses of 10(-8), 10(-6), 10(-4), or 10(-2) mg/mL, in stimulated cells the mycotoxins inhibited HOCl production proportionally to that of O2- because HOCl production is directly dependent on O2- generation. But unlike the others, zearalenol beta decreased HOCl production much more than one of O2-, indicating an effect also on myeloperoxidase secretion. All mycotoxins inhibited NO generation but only at the dose of 10(-2) mg/mL. Formyl-met-leu-phe-induced chemotaxis of neutrophils was deeply affected as well, as all mycotoxins at all doses used decreased it. All considered effects were not dose-dependent, likely connected to high variability of individual sensitivity to these compounds and because they already are present in blood introduced with foods. These activities of neutrophils confirm and extend the danger for immune systems by mycotoxins also in very small quantities, since the smaller concentrations we used are easily reachable in blood.


Jul 1, 1979·Infection and Immunity·S J Klebanoff
Nov 1, 1991·Veterinary Immunology and Immunopathology·D E Corrier
Sep 1, 1982·The Journal of Clinical Investigation·S J WeissM Wei
Aug 1, 1984·Toxicology and Applied Pharmacology·R YaromB Yagen
Feb 1, 1984·Toxicology and Applied Pharmacology·G A BoormanM I Luster
Nov 1, 1995·Journal of Leukocyte Biology·A M MilesM B Grisham
Dec 10, 1997·The Veterinary Record·L SilvottiE Cabassi
Nov 13, 1998·Infectious Diseases in Obstetrics and Gynecology·D T ShahB Larsen
Dec 22, 1998·Journal of Toxicology and Environmental Health. Part a·E Y MoonS Pyo
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ThuvanderI Gadhasson
Jun 2, 2000·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·G S Bondy, J J Pestka
Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L BerekJ Molnár
Sep 28, 2002·International Immunopharmacology·Charissa Dresden-Osborne, Gayle Pittman Noblet
Feb 8, 2003·Environmental Health Perspectives·Paul C TurnerChristopher P Wild
Aug 1, 2003·Immunopharmacology and Immunotoxicology·Adriana RichettiVincenzo Fimiani


Dec 1, 2010·Archives of Animal Nutrition·Ionelia TaranuIsabelle P Oswald
Jan 18, 2014·Journal of Medicinal Food·Maria T MonforteEnza M Galati
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
Nov 26, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Han QingqingLiu Shuqiang
Feb 22, 2013·Molecular Nutrition & Food Research·Thierry GauthierIsabelle P Oswald
Sep 1, 2015·Archives of Toxicology·Jia ShaoAd A C M Peijnenburg

Related Concepts

Chemotaxis, Leukocyte
Neutrophil Band Cells
Nitric Oxide

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.