Effect of myocrisin (sodium auro-thio-malate) on the morphogenesis of avirulent Semliki Forest virus in mouse brain: an electron microscopical study

Neuropathology and Applied Neurobiology
S Pathak, H E Webb

Abstract

Adult mice, infected intracerebrally or intraperitoneally with avirulent Semliki Forest virus, do not show mature virus or advanced stages of viral replication in the brain. If myocrisin is given intraperitoneally 3 h before the virus there is enhancement of all stages of viral replication and budding of virus and mature virions are seen. Compared with controls many intracytoplasmic smooth membrane vesicles were seen in the parenchymal cells of the brain treated with myocrisin or with myocrisin and virus. Myocrisin was visible in the brain and has a membrane proliferating effect which may enhance viral synthesis in the early stages of replication, as well as help in the assembly and budding of mature virus. Increased numbers of infiltrating cells were observed in myocrisin treated mice infected with SFV. The formation of mature virus, and its virulence, appears to be related to the degree of membrane proliferation of the brain cells. The inflammation associated with the increased number of infiltrating cells is secondary to this, the whole process promoting the death of the animals rather than survival.

References

Sep 1, 1970·Virology·L A Caliguiri, I Tamm
Sep 1, 1972·Journal of Virology·R M FriedmanI K Berezesky
Jan 1, 1970·Archiv für die gesamte Virusforschung·A Chiarini, E Norrby
Aug 1, 1961·The Journal of Biophysical and Biochemical Cytology·S DALES, L SIMINOVITCH

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