PMID: 8586775Jun 1, 1995Paper

Effect of N-3 polyunsaturated fatty acid supplemented diet on neutrophil-mediated ileal permeability and neutrophil function in the rat

Journal of the American College of Nutrition
A ChawlaS E Fisher

Abstract

Fish oil, rich in n-3 polyunsaturated fatty acids, can alter leukotriene production and hence neutrophil function, factors which may be important in the inflammation of Crohn's disease (CD). Therefore we studied the effect of dietary PUFA on neutrophil mediated ileal inflammation and neutrophil function in the rat. Animals were ad libitum-fed pellet diets containing 9.5% fish oil (menhaden oil, rich in n-3 PUFA) with 0.5% safflower oil, 10% safflower oil (rich in n-6 PUFA) or standard chow (6% fat) for 50 days prior to the study. Weight and circulating leukocyte and total neutrophil counts were identical in all three groups. Neutrophil mediated ileal inflammation induced by formyl-methionyl-leucyl-phenylalanine (fMLP) perfusion was evaluated by measuring macromolecular uptake of radiolabelled dextran (MW 70,000) and changes in mucosal neutrophil infiltration. The fish oil diet group showed no difference in fMLP-induced permeability changes relative to the Chow Control group. However, the Safflower Oil supplemented diet group had a reduced permeability response (p < 0.01). Mirroring the permeability changes, there was diminished mucosal neutrophil infiltration in the Safflower Oil group following ileal perfusion with fMLP (< .00...Continue Reading

References

Jan 1, 1978·Infection·T KalagerC O Solberg
Apr 15, 1992·Annals of Internal Medicine·W F StensonW Beeken
May 1, 1990·Digestive Diseases and Sciences·J L Wallace, C M Keenan
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·C O'MorainT O'Riordan
May 1, 1989·Atherosclerosis·E B SchmidtJ Dyerberg
Dec 1, 1987·Digestive Diseases and Sciences·E A LobosW F Stenson
Mar 1, 1988·Digestive Diseases and Sciences·M B Grisham, D N Granger
Aug 1, 1988·Digestive Diseases and Sciences·T KitahoraM Tsuchiya
Jan 1, 1988·Methods in Enzymology·A W Ford-HutchinsonJ F Evans
Jan 1, 1988·Advances in Immunology·R P MacDermott, W F Stenson
Jan 1, 1985·Methods of Biochemical Analysis·A K CampbellI Weeks
Jul 3, 1982·British Medical Journal·A D PearsonR Nelson

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Citations

Feb 17, 2001·The Journal of Nutritional Biochemistry·J E. Teitelbaum, W Allan Walker
Sep 16, 2006·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Angie Macdonald
May 24, 2008·European Journal of Nutrition·Linette E M WillemsenEric A F van Tol
Feb 20, 2021·Frontiers in Immunology·Abigail R BassonAlex Rodriguez-Palacios

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