Effect of N-acetylcysteine administration on homocysteine level, oxidative damage to proteins, and levels of iron (Fe) and Fe-related proteins in lead-exposed workers

Toxicology and Industrial Health
Sławomir KasperczykEwa Birkner

Abstract

N-Acetylcysteine (NAC) could be included in protocols designed for the treatment of lead toxicity. Therefore, in this study, we decided to investigate the influence of NAC administration on homocysteine (Hcy) levels, oxidative damage to proteins, and the levels of iron (Fe), transferrin (TRF), and haptoglobin (HPG) in lead (Pb)-exposed workers. The examined population (n = 171) was composed of male employees who worked with Pb. They were randomized into four groups. Workers who were not administered any antioxidants, drugs, vitamins, or dietary supplements were classified as the reference group (n = 49). The remaining three groups consisted of workers who were treated orally with NAC at three different doses (1 × 200, 2 × 200, or 2 × 400 mg) for 12 weeks. After the treatment, blood Pb levels significantly decreased in the groups receiving NAC compared with the reference group. The protein concentration was not affected by NAC administration. In contrast, Hcy levels significantly decreased or showed a strong tendency toward lower values depending on the NAC dose. Levels of the protein carbonyl groups were significantly decreased in all of the groups receiving NAC. Conversely, glutamate dehydrogenase activity was significantly el...Continue Reading

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Citations

Mar 24, 2016·Environmental Toxicology and Pharmacology·Sławomir KasperczykEwa Birkner
Jun 23, 2016·Environmental Toxicology and Pharmacology·Michał DobrakowskiSławomir Kasperczyk
Sep 7, 2012·Safety and Health at Work·Michele Augusto RivaGiancarlo Cesana
Apr 9, 2017·Biological Trace Element Research·Taíse F PedrosoMaria Ester Pereira
Nov 21, 2019·Mini Reviews in Medicinal Chemistry·Annalise R PfaffNuran Ercal
Sep 11, 2019·Drug and Chemical Toxicology·Michał DobrakowskiSławomir Kasperczyk
Jan 8, 2020·Antioxidants·Caterina LeddaVenerando Rapisarda
Jul 3, 2021·Antioxidants·Micaely Cristina Dos Santos TenórioMarília Oliveira Fonseca Goulart

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Methods Mentioned

BETA
protein folding
MDA
deamination

Software Mentioned

Statistica

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