Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice.

Cough
Junzo KameiAkiyoshi Saitoh

Abstract

Several observations have suggested that anandamide, an endogenous cannabinoid ligand, plays an important role in the modulation of cough sensitivity. However, it is unknown whether the anandamide membrane transporter plays a role in this modulation. To test this hypothesis, we investigated the effects of VDM11, an anandamide membrane transporter inhibitor, on capsaicin- and anandamide-induced cough. The effect of VDM11, an anandamide membrane transporter inhibitor, on capsaicin- and anandamide-induced cough in mice was examined. VDM11, at doses of 3-10 mg/kg subcutaneously, produced a dose-dependent antitussive effect. This antitussive effect was antagonized by pretreatment with either intraperitoneal administration (3 mg/kg) or inhalation (1 mg/ml) of SR141716A, a cannabinoid receptor (CB1) antagonist. However, intracerebroventricular injection of SR141716A (0.03 mg/mouse) did not alter the effect of VDM11. Exposure of mice to a nebulized solution of 10% DMSO, a vehicle of anandamide, induced a cough response (7.7 +/- 0.6 coughs/3 min; n = 10). Exposure of mice to a nebulized solution of anandamide, at concentrations of 0.03, 0.3 and 3 mg/ml, also produced a cough response in a concentration-dependent manner. The number of co...Continue Reading

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Aug 19, 2003·European Journal of Pharmacology·Kayo Morita, Junzo Kamei
Aug 13, 2004·European Journal of Pharmacology·Junzo KameiAkiyoshi Saitoh

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Citations

Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jun 4, 2016·International Urology and Nephrology·Masashi HondaAtsushi Takenaka
Mar 17, 2010·Biomedical Engineering Online·Malgorzata KrajnikEwa Jassem
Nov 7, 2021·Neurotoxicity Research·Karen Jaqueline Paredes-RuizAna Laura Colín-González
Dec 3, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Junzo Kamei

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