Effect of N-methyl-D-aspartate and inhibition of neuronal nitric oxide on collateral cerebral blood flow after middle cerebral artery occlusion

Neurosurgery
S C Robertson, C M Loftus

Abstract

To study the role of N-methyl-D-aspartate (NMDA) receptor activation and selective inhibition of neuronal nitric oxide synthase with 7-nitroindazole (7-NI) on blood flow to collateral-dependent tissue (CDT) after middle cerebral artery (MCA) occlusion. A left craniotomy was performed in each of 11 dogs with the animals under halothane anesthesia. A branch of the MCA was occluded and cannulated distally for determination of CDT, using a "shadow flow" technique. Cerebral blood flow (CBF) and vascular pressures were measured and used to calculate vascular resistance. Our shadow flow model has the ability to identify an area of CDT, with minimal contamination from overlap flow within a morphologically identified "risk area" for MCA branch occlusion. NMDA increased blood flow to CDT by 56.2%, while normal ipsilateral and contralateral cerebrum increased by at least 35% from baseline. 7-NI caused a significant drop in regional CBF, with the greatest drop of 41.7% occurring in the CDT. Normal ipsilateral and contralateral CBF was reduced by 31.7 and 23.9%, respectively. The dilator response to NMDA was significantly attenuated after 7-NI administration, except in CDT where flow increased ("inverse steal"). Cerebral vascular resistance...Continue Reading

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Citations

Jul 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Holly D Bauser-Heaton, H Glenn Bohlen
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Holly D Bauser-HeatonH Glenn Bohlen
Sep 25, 2003·Journal of Neuropathology and Experimental Neurology·Juan Manuel EncinasJosé Rodrigo

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