Effect of nafenopin (SU-13,437) on liver function: mechanism of choleretic effect.

Naunyn-Schmiedeberg's Archives of Pharmacology
W G LevineD K Mejier

Abstract

Administration of nafenopin (SU-13-437) to male rats for two days leads to a doubling of bile production and a 50% increase in liver weight. These two effects have been shown not to be directly interrelated. A marked decrease in biliary salt concentration suggests that the bile salt independent flow is stimulated. The extra bile produced is probably of canalicular origin since bile to plasma concentration ratios of erythritol are unchanged. At least three polar metabolites of nafenopin have been observed in rat bile. Observations in rats with partial biliary fistulas indicate that the drug and its metabolites undergo extensive entero-hepatic circulation. Our studies support the view that much of the enhanced bile flow is associated with the presence of nafenopin and/or its metabolites within the hepatobiliary system. However, the response is too extensive to be explained merely by osmotic choleresis. Induced structural changes in the liver may also account forsome of this effect.

References

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·G PaumgartnerG Grabner
May 15, 1973·Biochemical and Biophysical Research Communications·J ReddyD Azarnoff
Jun 1, 1972·The Journal of Clinical Investigation·H O Wheeler, K K King
Jan 1, 1970·Clinical Pharmacology and Therapeutics·J R BianchineL Lasagna
Sep 1, 1970·The Journal of Clinical Investigation·V MacarolS E Bradley
Sep 1, 1970·The American Journal of Physiology·P BerthelotA M Preaux
Apr 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·W G Levine
Sep 1, 1968·European Journal of Pharmacology·F W Koss, W Lamprecht
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E L ForkerH Sornson

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Citations

May 1, 1977·European Journal of Pharmacology·C RozéC Debray
Sep 24, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·D K MeijerW G Levine
May 15, 1977·Biochemical Pharmacology·W G LevineL A Stocken

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