Effect of nalidixic acid on DNA repair in rat hepatocytes

Cell Biology and Toxicology
C A McQueenG M Williams

Abstract

Nalidixic acid, a DNA topoisomerase inhibitor, has been reported to inhibit DNA repair in some mammalian systems. To investigate the effect of nalidixic acid on DNA repair in cultured rat hepatocytes, DNA damage was induced by ultraviolet light or N-methyl-N-nitro-N'-nitrosoguanidine. The presence of aphidicolin, a DNA polymerase alpha inhibitor resulted in a decrease in DNA repair. Nalidixic acid had no inhibitory effect. Neither aphidicolin nor nalidixic acid induced DNA repair. These results indicate that nalidixic acid does not damage DNA or inhibit DNA repair processes in hepatocytes.

References

Feb 1, 1985·Mechanisms of Ageing and Development·C J Maslansky, G M Williams
Feb 29, 1980·Science·N R Cozzarelli
Jan 1, 1981·Annual Review of Biochemistry·M Gellert
Sep 9, 1983·Biochimica Et Biophysica Acta·J M Clarkson, D L Mitchell

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Citations

Nov 1, 1991·Toxicology and Applied Pharmacology·C A McQueenG M Williams
Mar 4, 2000·Toxicology and Applied Pharmacology·H S YounisI G Sipes

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