PMID: 6187135Jan 1, 1982

Effect of nalidixic acid on the activation of RNA synthesis in outgrowing spores of Bacillus subtilis

Zeitschrift für allgemeine Mikrobiologie
M Hecker


Outgrowth of B. subtilis spores depends on the action of DNA gyrase (comp. Matsuda and Kameyama 1980). Application of nalidixic acid (100 micrograms/ml) to dormant spores of Bacillus subtilis prevents the outgrowth. Application of nalidixic acid (100 micrograms/ml) during the early outgrowth phase (after a 20 min germination period) does not prevent, but only delay spore outgrowth. Germination of spores is not influenced. Nalidixic acid is an effective inhibitor of RNA synthesis in outgrowing spores, whereas vegetative cells are more resistant. Spores can grow out inspite of a remarkably reduced intensity of RNA synthesis. Nalidixic acid particularly inhibits the synthesis of stable RNA, probably that of ribosomal RNA. We suggest that DNA gyrase-catalyzed alterations in DNA structure are involved in the regulation of the gene expressional program of outgrowing B. subtilis spores.


Mar 1, 1978·Journal of Bacteriology·G Satta, A B Pardee
May 1, 1979·Journal of Bacteriology·M GottfriedH O Halvorson
Feb 1, 1979·Journal of General Microbiology·A M AlbertiniA Galizzi
Sep 1, 1979·Molecular & General Genetics : MGG·A Sloma, I Smith
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·T OgawaH Ogawa
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A SuginoN R Cozzarelli
Jan 1, 1970·Zeitschrift für allgemeine Mikrobiologie·F Mach, H Engelbrecht
Jun 12, 1970·Science·J N HansenH O Halvorson
Jan 1, 1981·Zeitschrift für allgemeine Mikrobiologie·M HeckerF Mach
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R R Sinden, D E Pettijohn
Feb 29, 1980·Science·N R Cozzarelli
Sep 25, 1980·Nucleic Acids Research·B A Oostra, M Gruber
Jan 1, 1982·Zeitschrift für allgemeine Mikrobiologie·G Wachlin, M Hecker


Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·M Hecker

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