PMID: 6403964Jan 1, 1983Paper

Effect of naloxone and amphetamine on acquisition and memory consolidation of active avoidance responses in rats

Psychopharmacology
S Fulginiti, L M Cancela

Abstract

Pretraining IP injection of naloxone (0.3 mg/kg) or amphetamine (2 mg/kg) enhanced performance during acquisition, but did not improve retention of active avoidance responses in rats. Naloxone (0.1 or 3 mg/kg) had no effect on acquisition or on retention. The combination of naloxone (0.3 mg/kg) plus amphetamine (2 mg/kg) did not produce the facilitation observed when each of the two drugs was administered alone. Pretreatment with the higher dose of naloxone (3 mg/kg) blocked the facilitative effect of amphetamine on acquisition. Post-training administration of naloxone (0.3 mg/kg) or amphetamine (2 mg/kg) improved retention. Naloxone (0.1 or 3 mg/kg) had no effect. When naloxone and amphetamine were combined, at respective doses of 0.3 mg/kg and 2 mg/kg, the improvement did not occur, i.e., the higher dose of naloxone prevented the facilitative effect of amphetamine. In addition, an ineffective dose of amphetamine (0.5 mg/kg), given either pre- or post-training together with the lower dose of naloxone (0.1 mg/kg), produced a significant enhancement of acquisition or consolidation, respectively. The results are consistent with the possibility that naloxone might exert its facilitative action on acquisition and memory consolidati...Continue Reading

References

Jun 15, 1978·European Journal of Pharmacology·D De WiedH M Greven
Dec 21, 1976·Psychopharmacology·S FulginitiO A Orsingher
Aug 25, 1977·Nature·H PollardJ C Schwartz
Nov 9, 1978·Life Sciences·M Gallagher, B S Kapp
Nov 1, 1979·Behavioral and Neural Biology·R B MessingJ L McGaugh
Dec 1, 1978·Neuropharmacology·P W DettmarD S Walter
Aug 1, 1976·European Journal of Pharmacology·H D TaubeK Starke
Dec 1, 1976·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Jan 1, 1965·International Review of Neurobiology·J L McGaugh, L F Petrinovich
Jan 1, 1971·Psychopharmacologia·A M Evangelista, I Izquierdo
Apr 18, 1969·Science·L A Carr, K E Moore
Feb 4, 1980·Life Sciences·H RigterJ L McGaugh

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Citations

Jan 1, 1991·Psychopharmacology·K A TrujilloL Stein
Jan 11, 1992·Psychopharmacology·P H JanakJ L Martinez
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·W W Beatty
Apr 11, 1992·Pharmacology, Biochemistry, and Behavior·P H Janak, J L Martinez
Sep 1, 1984·Peptides·G A OlsonA J Kastin
Aug 13, 1998·Pharmacology, Biochemistry, and Behavior·C M CramerL D Reid
Jan 1, 1990·Annals of the New York Academy of Sciences·J E MorleyA J Silver
Jan 18, 2013·Journal of Psychopharmacology·Francesco LeriNorman M White
Oct 19, 2013·Journal of Clinical Psychopharmacology·Michael Edward BallardHarriet de Wit

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