PMID: 7213531Mar 1, 1981Paper

Effect of naproxen on glucose metabolism and tolbutamide kinetics and dynamics in maturity onset diabetics

British Journal of Clinical Pharmacology
B WhitingD S Robins

Abstract

1 The influence of the nonsteroidal anti-inflammatory drug naproxen on glucose metabolism and on tolbutamide pharmacokinetics and pharmacodynamics has been studied in ten maturity-onset diabetics. 2 Comparison of both plasma glucose decay curves and insulin responses during an intravenous glucose tolerance test before and after eight 12 hourly doses of naproxen revealed that naproxen had no significant influence on fasting glucose levels or on rates of glucose elimination. 3 When the subjects were given a combination of naproxen and tolbutamide for 3 days naproxen had no influence on tolbutamide absorption, protein binding, disposition or pharmacological effect. 4 Treatment with tolbutamide in maturity-onset diabetics need not be modified if concurrent administration of naproxen is contemplated.

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Citations

Aug 1, 1990·British Journal of Clinical Pharmacology·D HartmannW K Waldhäusl
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L C M DorneA G Renwick
Aug 1, 1988·Baillière's Clinical Rheumatology·A L Tonkin, L M Wing
Jun 3, 2010·The Annals of Pharmacotherapy·Martha M Rumore, Katelynn S Kim
Jul 1, 1982·British Journal of Clinical Pharmacology·P J MorrisonV A John

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