Mar 1, 1976

Effect of narcotic analgesics on the cortical control process of impulse transmission in the afferent pathways of the sciatic nerve

Farmakologiia i toksikologiia
V V Churiukanov, D P Bilibin


The effect produced by narcotic analgetics with their intravenous administration on the process of cortical control over the transmission of impulses along specific routes of the sciatic nerve was studied. The conditioning stimulation of the cortex was effected by using a monopolar electrode through single electric impulses. The interval between conditioning and test (on sciatic nerve) impulses was of 80-120 ms. Morphine (1-2 mg/kg), promedol (trimeperidin) (1-2 mg/kg) and phentanyl (100 gamma/kg) potentiated the inhibition of evoked potentials in the nucleus gracilis and in VPL, observed upon stimulation of the cortex of optic lobuses. The intensification of inhibitory corticifugal mechanisms occurring under the effect of narcotic analgetics takes place both on the level of the medulla oblongata and of the thalamic one.

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Mentioned in this Paper

Structure of Sciatic Nerve
Depression, Chemical
Meperidine Hydrochloride
Synaptic Transmission
Potentials, Event-Related
Insula of Reil
Morphine Sulfate (2: 1), Pentahydrate
Visual Cortex
Afferent Pathways

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