Abstract
Sirtuin 1 (SIRT1), a histone/protein deacetylase, has been implicated in aging, metabolism, and stress resistance. SIRT1 regulates endothelial nitric oxide (NO) synthase, restores NO availability, and is involved in different aspects of cardiovascular disease. The aim of this study was to evaluate any abnormalities with regard to SIRT1 protein level in the blood, SIRT1 activity, and impaired endothelial function in patients with obstructive sleep apnea syndrome (OSAS). We also investigated whether or not OSAS patients who received nasal continuous positive airway pressure (CPAP) treatment showed improvements in the levels of SIRT1. Thirty-five patients with moderately severe to severe OSAS who requested nasal CPAP treatment and 20 healthy controls were prospectively enrolled. The SIRT1 protein levels in blood and its activity, and the serum levels of nitric oxide derivative (NO x ) were assessed. All subjects participated in sleep studies, which were repeated 3 months after nasal CPAP treatment in the patients with OSAS. In the patients with OSAS, the level of SIRT1 in the blood, its activity, and that of NO x was lower than those of normal subjects before nasal CPAP treatment. After nasal CPAP treatment, the level of SIRT1 in ...Continue Reading
References
Jun 1, 1995·Annals of Medicine·R Busse, I Fleming
Sep 30, 2000·The New England Journal of Medicine·W PankowF W Lohmann
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C SittipuntT R Martin
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Mary S M IpKaren S L Lam
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Yüksel PekerJan Carlson
Feb 15, 2003·Sleep Medicine Reviews·Lena Lavie
Mar 2, 2005·The European Respiratory Journal·P J BarnesK Ito
Aug 9, 2005·DNA Repair·Marcin Kruszewski, Irena Szumiel
Apr 24, 2007·The Biochemical Journal·Shaday Michan, David Sinclair
Jan 5, 2008·American Journal of Respiratory and Critical Care Medicine·Saravanan RajendrasozhanIrfan Rahman
Feb 23, 2008·Nature Reviews. Molecular Cell Biology·Xiang-Jiao Yang, Edward Seto
Nov 11, 2008·Recent Patents on Cardiovascular Drug Discovery·Sivaram Pillarisetti
Dec 17, 2008·Thorax·A Alonso-FernándezA Agustí
Mar 6, 2009·Geriatrics & Gerontology International·Li ZengShigeto Morimoto
Apr 21, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuji NakamaruKazuhiro Ito
Mar 11, 2010·Journal of Atherosclerosis and Thrombosis·Hidetaka OtaYasuyoshi Ouchi
Dec 20, 2011·Preventive Medicine·Irfan RahmanHongwei Yao
Jul 17, 2012·Biochemical Pharmacology·Hongwei Yao, Irfan Rahman
Sep 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jae-Woong HwangIrfan Rahman
Dec 3, 2013·Canadian Journal of Physiology and Pharmacology·Yi Xin HuLin Liu
Oct 30, 2014·Molecular Medicine Reports·Qiuyan WangLi Zhao
Citations
Apr 9, 2020·Journal of Sleep Research·Mirjam LjunggrenEva Lindberg
Jul 22, 2018·Clinical Oral Investigations·Ching-Chi LinMei-Wei Lin
Jun 19, 2019·International Journal of Molecular Sciences·Yung-Che ChenMeng-Chih Lin
Dec 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laetitia S GasparAlexandrina Ferreira Mendes
Jun 3, 2021·International Journal of Molecular Sciences·Jakub MocholAdrian Doroszko