Effect of nasal steroid treatment on airway inflammation determined by exhaled nitric oxide in allergic schoolchildren with perennial rhinitis and asthma

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Christophe PedrolettiGunilla Hedlin

Abstract

Rhinitis is common in asthmatic schoolchildren who are allergic to animal dander and constantly and indirectly exposed to these allergens in their everyday environment. As a patho-physiological linkage between nasal and bronchial inflammation has been proposed to exist, the primary objective of this study was to determine whether nasal administration of mometasone furoate (MSNF) can reduce bronchial inflammation, as reflected in the level of exhaled nitric oxide (F(E)NO) in asthmatic schoolchildren with dander allergy and mild-to-moderate rhinitis. Forty such children were assigned randomly to be treated for 4 wk with MSNF or placebo, employing a double-blind procedure. F(E)NO was the primary end-point measured and secondary end-points were nasal levels of NO, the concentration of eosinophilic cationic protein (ECP) in nasal lavage, the relative numbers of eosinophils in blood, forced expiratory volume in 1 s (FEV(1)), peak expiratory flow (PEF) and scoring of symptoms. There was no significant difference in the F(E)NO values of the treated and control groups at any time-point, whereas the nasal level of ECP was lower in the treated group compared with placebo (p = 0.05) on both days 7 and 28, and compared with baseline for the...Continue Reading

Associated Clinical Trials

References

Feb 1, 1995·The European Respiratory Journal·S A KharitonovP J Barnes
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·J R ShaverS P Peters
Apr 1, 1995·Nature Medicine·J O LundbergK Alving
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A Wood, P A Eggleston
Jan 1, 1994·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·R J SettipaneG A Settipane
Feb 1, 1993·The American Review of Respiratory Disease·S M BrugmanC G Irvin
Nov 1, 1995·Archives of Disease in Childhood·A LindforsS L Nordvall
Aug 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M DrouinB N Lutsky
Feb 1, 1996·The European Respiratory Journal·S A KharitonovP J Barnes
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L Klimek, G Rasp
Jun 9, 1999·The Journal of Allergy and Clinical Immunology·C AlmqvistM Wickman
Jun 9, 1999·The Journal of Allergy and Clinical Immunology·M S PerzanowskiT A Platts-Mills
Nov 24, 1999·Allergy·A Togias
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·G J BraunstahlW J Fokkens
Mar 10, 2001·The Journal of Allergy and Clinical Immunology·G J BraunstahlW J Fokkens
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Robert J AdamsScott T Weiss
Feb 18, 2003·The Journal of Allergy and Clinical Immunology·Alessandra SandriniKenneth R Chapman
Jun 6, 2003·The Journal of Allergy and Clinical Immunology·Alkis Togias
Dec 25, 2003·The Journal of Allergy and Clinical Immunology·Alkis Togias

❮ Previous
Next ❯

Citations

Dec 17, 2008·Current Opinion in Pulmonary Medicine·Anne E Dixon
Apr 11, 2012·American Journal of Rhinology & Allergy·A Fusun Kalpaklioglu, Ilkay K Kalkan
Oct 14, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Sverre K Steinsvåg
Dec 1, 2008·Expert Review of Respiratory Medicine·Barbara P Yawn
Aug 27, 2014·Pediatric Pulmonology·Angelo MannaFrancesca Santamaria
Dec 16, 2011·Pediatric Pulmonology·Elin T G KerstenJean M M Driessen
Mar 24, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Seiichiro MakiharaKazunori Nishizaki
Oct 12, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tammy S JacobsJuan C Celedón
Sep 2, 2014·The Journal of Allergy and Clinical Immunology·Anne E DixonRobert A Wise
May 25, 2016·Expert Opinion on Investigational Drugs·Howraman Meteran, Vibeke Backer
Jul 26, 2013·American Journal of Rhinology & Allergy·Ina CallebautPeter W Hellings
Mar 7, 2012·American Journal of Rhinology & Allergy·Maciej CiebiadaPawel Gorski
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Nov 10, 2011·International Journal of Immunopathology and Pharmacology·G L MarsegliaM La Rosa
Dec 17, 2008·Current Opinion in Pulmonary Medicine
Sep 19, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Christina KrantzUNKNOWN European Community Respiratory Health Survey III

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Christophe PedrolettiGunilla Hedlin
The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Nicola ScichiloneVincenzo Bellia
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Aharon KesselElias Toubi
© 2022 Meta ULC. All rights reserved