Effect of Nauclea subdita (Korth.) Steud. leaf extract on hematological and histopathological changes in liver and kidney of striped catfish infected by Aeromonas hydrophila

Veterinary World
Siti AisiahAting Yuniarti

Abstract

The present study was conducted to investigate the efficacy of different doses of Bangkal (Nauclea subdita) leaf extract on hematological and histological changes in kidney and liver of catfish (Pangasius hypophthalmus) infected by Aeromonas hydrophila. Catfish were experimentally infected with A. hydrophila at a dose of 108 cells/mL through intraperitoneal injection, and the hematological and histological changes in the kidney and liver of catfish against the pathogen were observed. Not all concentrations of N. subdita caused a toxic effect in striped catfish. The clinical symptoms of catfish after infection with A. hydrophila and treatment with N. subdita leaf extract included morphological and behavioral changes. N. subdita leaf extract reduced mortality caused by A. hydrophila. Treatment with N. subdita leaf extract was effective in reducing the inflammation by decreasing the activity of neutrophils, monocytes, and lymphocytes. The Hb and Ht levels of catfish significantly decreased after exposure to 108 cells/mL of A. hydrophila and increased significantly after N. subdita treatment. Necrosis percentages in the kidney and liver also decrease after N. subdita treatment. The results indicate that N. subdita leaf extract stim...Continue Reading

References

May 14, 2005·Fish & Shellfish Immunology·Ian Bricknell, Roy A Dalmo
Sep 8, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingzhe Gao, Hongbin Xiao
Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sook Yee LiewKhalijah Awang
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