Effect of nebivolol on beat-to-beat and short-term blood pressure variability in spontaneously hypertensive rats.

Naunyn-Schmiedeberg's Archives of Pharmacology
Facundo Martín BerteraChristian Höcht

Abstract

Cardiovascular effects and pharmacokinetics of nebivolol were assessed in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) animals. Male SH and WKY rats were treated with vehicle or nebivolol 0.3, 3, or 10 mg kg(-1) (i.v.) and effects on blood pressure (BP), heart rate, and blood pressure variability (BPV) were recorded. Plasma pharmacokinetics of d- and l-nebivolol was studied by traditional blood sampling. Short-term and beat-to-beat BPV was assessed by standard deviation and spectral analysis of BP recording, respectively. Nebivolol showed enantioselective pharmacokinetics in both experimental groups; clearance of l-nebivolol was significantly greater than d-enantiomer. Clearance of nebivolol was significantly reduced in SHR with regards to WKY animals. Hypotensive response to nebivolol 3 and 10 mg kg(-1) was significantly enhanced in SHR compared with normotensive animals. Spectral analysis of beat-to-beat BPV showed a greater reduction in low frequency BPV in SHR than in WKY rats. Nebivolol 3 and 10 mg kg(-1) significantly reduced ratio low frequency/high frequency BPV only in SHR. Short-term BPV was markedly reduced by nebivolol 0.3, 3, and 10 mg kg(-1) in WKY and SHR. In conclusion, the hypertensive stage in ...Continue Reading

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Citations

Feb 1, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Facundo Martín BerteraChristian Höcht
Mar 7, 2014·Canadian Journal of Physiology and Pharmacology·Karla Fabiana GoesslerMarcos Doederlein Polito
Mar 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·Christian HöchtCarlos Alberto Taira
Sep 21, 2013·Clinical and Experimental Hypertension : CHE·Nihal OzkayarYunus Erdem
Oct 13, 2014·Orvosi hetilap·Ede Kékes, István Kiss
Oct 18, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Facundo Martín BerteraChristian Höcht
Oct 26, 2018·Hypertension·Michal BehuliakJosef Zicha

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