PMID: 8939176Nov 1, 1996Paper

Effect of nedocromil sodium pretreatment on the immediate and late responses of the airway to segmental antigen challenge

The Journal of Allergy and Clinical Immunology
W J CalhounW W Busse

Abstract

In many patients with asthma, exposure to allergen results in worsening symptoms, pulmonary dysfunction, and increased airway inflammation. In this study, segmental allergen challenge and bronchoalveolar lavage were used to evaluate the airway responses at 5 minutes and 48 hours and to study the extent of inhibition of the response by pretreatment with nedocromil sodium in eight subjects with allergic asthma in a double-blind, placebo-controlled trial. At 5 minutes after challenge, nedocromil sodium pretreatment significantly reduced histamine concentrations, with a trend toward a concomitant reduction in tryptase levels. Nedocromil sodium did not affect the increase in total protein, total cell counts, or cell concentrations that occurred 48 hours after challenge, but it did significantly reduce eosinophil recruitment. Eosinophil activation, assessed as release of granule proteins, was unaffected. A significant positive correlation was shown between the degree of histamine reduction at 5 minutes and the degree of reduction of eosinophil influx at 48 hours, raising the possibility that eosinophil influx into the airway may depend on mediators or cytokines released during the immediate response to allergen.

Citations

Nov 1, 1996·The Journal of Allergy and Clinical Immunology·E R BleeckerW C Moore
Oct 27, 1998·Allergy·P M O'ByrneL J Wood
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·N N JarjourW J Calhoun
Apr 3, 2001·American Journal of Respiratory and Critical Care Medicine·W J CalhounJ J Kratzenberg
Jan 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C MappL M Fabbri
Apr 17, 1999·Clinics in Chest Medicine·M S KavuruM J Thomassen
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved