Effect of Needle Size on Pain Perception in Patients Treated With Botulinum Toxin Type A Injections: A Randomized Clinical Trial

JAMA Dermatology
Murad AlamKira Minkis

Abstract

Transcutaneous injection through smaller hollow-bore needles may decrease patient discomfort, but current evidence is equivocal. To compare injection discomfort in patients treated with botulinum toxin type A with 30- and 32-gauge needles. Split-face, patient- and injector-blinded randomized clinical trial at the dermatology service of an urban university medical center. The 20 participants were women aged 25 to 70 years in good health and with moderate dynamic forehead and glabellar wrinkles. Data were collected from November 20, 2013, through January 16, 2014. Follow-up was complete on January 16, 2014. Data from the per-protocol population were analyzed from July 1 to July 31, 2014. One side of each patient'sforehead received botulinum toxin type A in saline injected with a 32-gauge needle; the other side received the same treatment injected with a 30-gauge needle. In addition, each patient received randomized injections of saline only to both upper inner arms with the same types of needles. Primary outcomes included the patient-reported pain rating on a visual analog scale (VAS) on either side of the face and arms and the proportion of patients whose VAS ratings corresponded with more than moderate (ie, clinically significa...Continue Reading

Citations

Aug 16, 2016·Journal of Voice : Official Journal of the Voice Foundation·Wonjae ChaMin-Gyu Jo
Apr 8, 2017·Aesthetic Surgery Journal·Mark NestorAndy Pickett
Oct 11, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Blake R ZelicksonWesley J Wu
Feb 27, 2020·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Hermine WarrenSarah Coquis-Knezek
Sep 10, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Osman Akyüz, Müslüm Ergün
Jan 3, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rashek KaziBryan T Carroll
Dec 20, 2019·Science Translational Medicine·Kevin J McHughAna Jaklenec
Dec 1, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mark S NestorAndy Pickett

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