Effect of negative pressure wound therapy on molecular markers in diabetic foot ulcers

Gene
Rehab A KaramMohamed Al Saeed

Abstract

Diabetic foot ulcers are one of the most common complications of diabetes with high morbidity and mortality. Negative pressure wound therapy (NPWT) is one of the treatment modalities that facilitates the wound healing process; however, its molecular mechanism remains unclear. The aim of this study was to investigate the mechanism of action of NPWT in the treatment of diabetic foot ulcers via measuring the tissue expression of genes related to the wound healing process. The study included 40 patients with diabetic foot ulceration, 20 of them received NPWT and the other 20 were a control group treated with advanced moist therapy. Granulation tissue biopsies were obtained before and 10 days after treatment in both groups and subjected to real-time polymerase chain reaction to measure the mRNA expression of TGF-β1, VEGF, TNF-α, IL-1β, MMP-1, MMP-9 and TIMP-1 which are involved in the wound healing pathway. After 10 days of treatment with NPWT, the mRNA levels of IL-1β, TNF-α, MMP-1, and MMP-9 were significantly downregulated, while the levels of VEGF, TGF-β1 and TIMP-1 were significantly increased. Our study demonstrated that NPWT promotes wound healing in diabetic foot ulcers possibly by affecting growth factors, inflammatory cyto...Continue Reading

Citations

Jul 19, 2019·Cells·Letizia FerroniBarbara Zavan
Jan 3, 2019·European Journal of Clinical Investigation·Sebastian BorysMaciej T Malecki
Jul 27, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T CurranD Nagle
Dec 30, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Cody C FrearLeila Cuttle
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou
Apr 27, 2021·Frontiers in Immunology·Zoya VerseyEdana Cassol
Dec 8, 2021·Expert Opinion on Therapeutic Targets·Jonathan Golledge, Shivshankar Thanigaimani
Dec 9, 2021·The International Journal of Lower Extremity Wounds·Kirsi IsoherranenLiisa Väkevä

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