Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Luís A PiresR C Maranhão

Abstract

Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LDL receptor-related protein 1 (LRP-1) receptors in breast carcinoma. Fragments of tumoral and normal breast tissue from 16 consecutive volunteer women with breast cancer in stage II or III were obtained from biopsies before the beginning of neoadjuvant chemotherapy and after chemotherapy, from fragments excised during mastectomy. Tissues were analyzed by immunohistochemistry for both receptors. Because complete response to treatment was achieved in 4 patients, only the tumors from 12 were analyzed. Before chemotherapy, there was overexpression of LDL receptor in the tumoral tissue compared to normal breast tissue in 8 of these patients. LRP-1 receptor overexpression was observed in tumors of 4 patients. After chemotherapy, expression of both receptors decreased in the tumors of 6 patients, increased in 4 and was unchanged in 2. Nonetheless, even when chemotherapy reduced rece...Continue Reading

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Citations

Feb 28, 2014·BMC Cancer·Catarina Rodrigues Dos SantosJ C Mendes de Almeida
Dec 17, 2014·International Journal of Molecular Sciences·Ling Lin, Kebin Hu
Oct 23, 2012·Journal of Cellular Physiology·Ahmed A RehmanFahim H Khan
May 11, 2018·International Journal of Cancer. Journal International Du Cancer·Rui GaoWei Xu
Aug 28, 2020·Frontiers in Oncology·Océane CampionJérôme Devy
Dec 28, 2015·Nanomaterials·Shanshan WangRongqin Huang
Jun 19, 2019·Journal of Clinical Medicine·Lídia CedóJoan Carles Escolà-Gil
Jun 12, 2019·Lipids in Health and Disease·Xuefeng GuanYu Ding
Feb 21, 2021·Drug Discovery Today·Shreya PawarArun K Iyer
Mar 10, 2021·Critical Reviews in Food Science and Nutrition·Michał SienkiewiczJakub Fichna
Nov 30, 2020·Seminars in Cancer Biology·Giovanna RevillaJoan Carles Escolà-Gil

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Methods Mentioned

BETA
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