Effect of neonatal handling on serotonin 1A sub-type receptors in the rat hippocampus

Neuroscience
A StamatakisFotini Stylianopoulou

Abstract

Serotonin 1A sub-type receptors play an important role in the etiopathogenesis of depression, which is known to occur more often in females than males. Early experiences can be a predisposing factor for depression; however, the underlying cellular processes remain unknown. In an effort to address such issues, we employed neonatal handling, an experimental model of early experience, which has been previously shown to render females more vulnerable to display enhanced depression-like behavior in response to chronic stress, while it increases the ability of males to cope. In rat pre-pubertal (30 days of age) and adult (90 days) hippocampus, of both males and females, the effect of neonatal handling on serotonin 1A sub-type receptor mRNA and protein levels was determined by in situ hybridization and immunohistochemistry, respectively, while the number of binding sites was determined by in vitro autoradiography using [(3)H]8-hydroxy-2(di-n-propylamino)tetralin as the ligand. Our results revealed a significant sex difference in serotonin 1A sub-type receptor mRNA, protein and binding sites, with females having higher levels than males. Handling resulted in statistically significant decreased numbers of cells positive for serotonin 1A...Continue Reading

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Citations

Aug 18, 2010·Psychopharmacology·Hirokazu MatsuzakiMitsuhiro Yoshioka
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Jan 28, 2014·Applied and Environmental Microbiology·Allana WelshRobert A Sanford
Aug 14, 2020·Genome Biology and Evolution·Kelsey Aadland, Bryan Kolaczkowski

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