Effect of neonatal surfactant therapy on lung function at school age in children born very preterm

Pediatric Pulmonology
A S PelkonenM Hallman

Abstract

Our aim was to evaluate long-term effects of exogenous surfactant therapy on pulmonary functional outcome in children born very preterm. We examined 40 children aged 7-12 years who were born before 30 weeks of gestation with an immature surfactant system, and were randomized to one of three treatment groups: human surfactant given at birth (prophylactic), human surfactant given after development of neonatal respiratory distress syndrome (rescue), and placebo (air) treatment. Spirometric parameters of preterm born children were compared with those of 20 children born at term. In addition, spirometric parameters were monitored twice daily for 4 weeks using a home spirometer. All spirometric parameters were significantly lower in the preterm groups than in the controls, except for the forced vital capacity (FVC) in the prophylactically treated group. Bronchial obstruction was found in 53% of the prophylactically treated group, in 36% of the rescue group, in 67% of the placebo group, and in 0% of the control group. Peak expiratory flow (PEF) and FVC values were higher in those children who received surfactant compared with the placebo group (P < 0.05). In 16 children (40%) born preterm, a beta2-agonist induced an increase in PEF > ...Continue Reading

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Citations

Nov 19, 2013·Seminars in Fetal & Neonatal Medicine·Anne-Marie Gibson, Lex W Doyle
Apr 2, 2003·Seminars in Neonatology : SN·Mikko Hallman, Ritva Haataja
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M HallmanM Rämet
Aug 29, 2000·Pediatric Research·B BrennerO Linderkamp
Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·A S PelkonenM Turpeinen
Jan 15, 2000·Journal of Paediatrics and Child Health·J D Kennedy
Apr 18, 2006·Pediatric Pulmonology·Lex W Doyle, UNKNOWN Victorian Infant Collaborative Study Group
Aug 8, 2013·Therapeutic Delivery·Nashwa El-GendyPrajnaparamita Dhar
Jul 9, 2020·Frontiers in Pediatrics·James T D GibbonsShannon J Simpson
Jul 15, 2017·American Journal of Respiratory and Critical Care Medicine·Lex W DoyleJeanie L Y Cheong
Mar 16, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Francesca CiuffiniDavid G Tingay
Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll
Feb 5, 2008·Pediatrics·William A Engle, UNKNOWN American Academy of Pediatrics Committee on Fetus and Newborn

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