PMID: 9533420Apr 9, 1998Paper

Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats

Journal of Hypertension
G Simon, B Csiky

Abstract

In a previous study, we found that neonatal sympathectomy prevented the development of angiotensin II (ANG II)-induced hypertension but not the development of structural changes in small mesenteric arteries. To investigate further the dissociation between hypertension and structural vascular changes in sympathectomized ANG II-treated rats by extending morphometric measurements to include all segments of the mesenteric arterial tree. Neonatally sympathectomized and sham-sympathectomized male Sprague-Dawley rats, aged 34 months, were administered 200 ng/kg per min ANG II subcutaneously for 4 weeks. Sham-operated sympathectomized and sham-sympathectomized rats were controls. At the end of the treatment period the mesenteric circulation of rats was perfusion-fixed for morphometric measurements. Tail systolic blood pressure in ANG II-treated sham-sympathectomized rats increased by 47 mmHg (P < 0.001); the increase of systolic blood pressure (11 mmHg) in ANG II-treated sympathectomized rats did not attain statistical significance. Sympathectomy alone increased the lumen and reduced the wall : lumen ratio of first- and second-order branches of the superior mesenteric artery (hypotrophic outward remodeling). ANG II treatment increased ...Continue Reading

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Citations

May 24, 2007·Current Hypertension Reports·John W OsbornMohan K Raizada
Sep 5, 2002·Clinical and Experimental Pharmacology & Physiology·Rohit RamchandraSimon C Malpas
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·John P Collister, Michael D Hendel
Oct 20, 2011·Cardiovascular Diabetology·Markus ReschDierk H Endemann
Feb 5, 2016·Autonomic & Autacoid Pharmacology·I A Gallardo-OrtízR Villalobos-Molina
Aug 15, 2009·Autonomic Neuroscience : Basic & Clinical·Houcine DabKamel Kacem
Apr 27, 2004·Journal of Hypertension·Geza Simon
Feb 6, 2008·Cardiovascular Research·François FeihlBernard Waeber
Jul 6, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Marcos T KurokiJohn W Osborn
Aug 10, 2000·American Journal of Hypertension·G IllyesG Simon

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