PMID: 6165443Jun 9, 1981Paper

Effect of nerve activity on transport of nerve growth factor and dopamine beta-hydroxylase antibodies in sympathetic neurones

Brain Research
G J LeesR Rush

Abstract

The effect of nerve activity on the uptake and retrograde transport of nerve growth factor (NGF) and dopamine beta-hydroxylase (DBH) antibodies was studied by injecting 125I-labelled NGF and anti-DBH into the anterior eye chamber of guinea-pigs. Decentralization of the ipsilateral superior cervical ganglion (SCG) had no significant effect on the retrograde transport of either NGF or anti-DBH. Phenoxybenzamine produced a 50% increase in anti-DBH but not NGF accumulation and this effect was prevented by prior decentralization. This demonstrates that NGF is taken up independently of the retrieval of synaptic vesicle components.

Citations

Apr 1, 1986·Journal of Neurocytology·P J FinnR A Rush
Dec 1, 1992·Pharmacology & Therapeutics·I A Hendry
Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·R A RushX F Zhou
Jan 6, 2004·Journal of Neurobiology·M W Weible, I A Hendry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.