PMID: 15378137Sep 21, 2004Paper

Effect of nesiritide on length of hospital stay in patients with decompensated heart failure

Journal of Cardiovascular Pharmacology and Therapeutics
Richard ChangJ Thomas Heywood

Abstract

We examined the effect of nesiritide, administered as initial therapy, on length of hospital stay (LOS) and renal function through a retrospective analysis of 129 consecutive admissions to the coronary care unit in 98 patients diagnosed with congestive heart failure. Nesiritide was infused during 58 admissions (nesiritide group) while other therapies, not including nesiritide, were used during 71 admissions (non-nesiritide group). Although the nesiritide group showed lower baseline left ventricular ejection fraction and systolic blood pressure, higher serum creatinine, and a longer QRS interval, the LOS of this group was significantly shorter compared to the non-nesiritide group (3.91 +/- 1.3 vs 4.77 +/- 1.7 days, P = .0023). Both groups were similar with respect to body weight change (negative fluid balance), a slight decrease in blood urea nitrogen, and unchanged serum creatinine. Nesiritide as an initial therapy for treatment of congestive heart failure results in a more rapid hospital discharge without compromising renal function.

References

Mar 15, 1989·Journal of the American College of Cardiology·W W Parmley
May 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D H Ellison
Jul 26, 2002·Journal of Cardiac Failure·Stephen S GottliebHarlan M Krumholz

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Citations

Jul 11, 2006·Pediatric Cardiology·J L JefferiesJ A Towbin
Sep 6, 2005·Current Heart Failure Reports·J Thomas Heywood, Mitchell T Saltzberg
Sep 25, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Noritake HataMasahiko Kinoshita
Mar 3, 2006·Pharmacotherapy·Tobias GerhardAbraham G Hartzema
Dec 17, 2008·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Tariq Khan, J Thomas Heywood
Sep 27, 2006·Pharmacotherapy·Michael P Dorsch, Jo Ellen Rodgers
Dec 13, 2005·Current Opinion in Nephrology and Hypertension·Marc A Silver

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