PMID: 9418963Jan 7, 1998Paper

Effect of neu differentiation factor isoforms on neonatal oligodendrocyte function

Journal of Neuroscience Research
Timothy D RaabeG H Devries

Abstract

Previous studies have suggested that neu differentiation factor (NDF), a member of the neuregulin (NRG) family of growth factors, may regulate the development of PNS and CNS glial cells. There is limited information concerning the potential role of NDF on the development of neonatal (immature) oligodendrocytes (OLG) into adult OLG. We now report the effect of the two major isoform families of NDF (NDF alpha and NDF beta) on the development of cultured rat neonatal OLG. Immunocytochemical and western blot analyses of neonatal OLG using anti-erb-B antibodies revealed that these immature OLG express all four members of NRG (erb-B) receptors. Treatment of neonatal OLG with varying concentrations of either NDF alpha or NDF beta did not have a mitogenic effect on cultured neonatal OLG. Pretreatment of immature OLG with either of the NDF isoforms also did not influence the subsequent mitogenicity of other known OLG mitogens. However, treatment of neonatal OLG with either isoform of NDF influenced the survival of these cells by protecting the cells from apoptosis. Additionally, treatment of neonatal OLG with either NDF alpha or NDF beta resulted in more extensive process formation compared to control, non-treated OLG.

References

May 22, 1992·Science·W E HolmesG D Lewis
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O BöglerM Noble
Jan 1, 1989·Journal of Neurochemistry·S J Chen, G H DeVries
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Aug 15, 1995·Journal of Neuroscience Research·J R FrancoeurS Carbonetto
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·T VartanianK Stefansson
Jul 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·N Ben-Baruch, Y Yarden
Jun 15, 1994·Journal of Neuroscience Research·T J NeubergerG H De Vries
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·R Pinkas-KramarskiY Yarden
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Orr-UrtregerY Yarden
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D Meyer, C Birchmeier
Oct 1, 1995·Current Opinion in Neurobiology·K L Carraway, S J Burden
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·D E SyroidT J Kilpatrick
Oct 15, 1996·Journal of Neuroscience Research·T D RaabeG H DeVries
Mar 15, 1996·Journal of Neuroscience Research·L MinghettiP Stroobant
Feb 12, 1998·Journal of Neurochemistry·T D RaabeG H DeVries
Mar 3, 1998·Neurochemical Research·T D RaabeG H DeVries

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Citations

Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·T VartanianR Miller
Dec 22, 1999·The Journal of Cell Biology·B A Barres, M C Raff
Oct 6, 1999·The European Journal of Neuroscience·H I KornblumK B Seroogy
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E Jaros, D J Burn
Jan 14, 2000·Glia·K Adlkofer, C Lai
Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Apr 7, 2005·Glia·Patricia S RitchHarald Sontheimer
Dec 26, 2008·Neurochemical Research·George H DeVries
Jul 6, 2000·Journal of Neuroscience Research·R J ThompsonS C Barnett
Apr 8, 1999·Molecular and Cellular Neurosciences·P D CanollJ L Salzer
May 20, 2004·Experimental Cell Research·Pamela E Knapp, Mary H Adams
Nov 24, 2004·Molecular and Cellular Neurosciences·Kimberly M GereckeSteven L Carroll

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