PMID: 558110Jan 1, 1977Paper

Effect of neuroleptics, midantan and DOPA on apomorphine sterotypy in rats

Farmakologiia i toksikologiia
V V Kalinin

Abstract

The influence of differently structured neuroleptics on the stereotypyd attitude of rats, induced by apomorphine, was inquired into. Most of the known neuroleptics manifested an inhibitory effect on the apomorphine-induced stereotypy. Clozapine and azabutyrone were effective only in a dose of 25 mg/kg, while carbidine and promazine failed to exert any marked influence on the stereotypy. It seems that the antiapomorphine effect does not correlate with the antipsychotic activity of the neuroleptics.

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